The two days PFI 37th AGM witnessed the presence of over 950 plus participants from across India and 111 sponsoring companies, reflecting the strength and unity of India’s poultry community. The AGM began with the lighting of the ceremonial lamp, symbolizing growth, progress and prosperity in the poultry sector.

Mr. Ranpal Dhanda, President, Poultry Federation of India, welcomed all participants, expressing heartfelt gratitude to all sponsoring companies for their valuable support in making this 37th AGM a grand success with their presence. PFI President said this PFI AGM is an occasion where the entire country’s poultry sector has gathered on a single platform to connect, share experiences and deliberate on the future course of action. The entire value chain of the poultry sector is present on this platform—ranging from farmers, breeders, feed millers, and integrators to medicine and equipment companies, doctors, scientists, and associations. And therein lies PFI’s greatest strength. Mr. Dhanda added we must place equal emphasis on technology, scientific knowledge, disease management, feed quality, genetics, biosecurity, and modern farming practices. Our aim is to ensure that the knowledge possessed by scientists and experts does not remain confined to conferences and laboratories; the benefits of research must reach the farm level. In this context, VIV Select India 2026 has been a significant milestone for us. Mr. Ranpal Dhanda further said India is a young nation today, and one of our greatest challenges is delivering affordable, high-quality nutrition to as many people as possible. Eggs and chicken play a vital role in this. For us, these are not merely poultry sector products; they are crucial components of nutritional and protein security. Therefore, in the future, PFI will vigorously advance the “Mission Protein India” initiative. We will strive to disseminate accurate, scientific information regarding the nutritional benefits of eggs and chicken to the public through awareness programs, social media, digital platforms, and other communication channels. Our objective is to address the misconceptions and misinformation surrounding poultry products in the country by presenting facts and scientific evidence. Today, we have many young professionals, entrepreneurs, veterinarians, and next-generation poultry farmers among us. PFI will strive to bring the youth into the fold of the organization, giving them an opportunity to voice their views and play a role in the future leadership of the sector. After all, the poultry sector of the next 10–20 years will be in the hands of today’s youth.

The inaugural address was followed by the Annual Report presented by
Mr. Ravinder Singh Sandhu, Secretary, who highlighted following activities being done by PFI in last one year.

Regarding the Bird Flu Vaccine Policy: Bird Flu has been a major concern for farmers. PFI has consistently raised the issue of LPAI and HPAI vaccines with the government. As you all know, the PFI team worked hard to secure permission for the LPAI vaccine and maintained continuous coordination with the Department of Animal Husbandry (Government of India) regarding the HPAI vaccine. PFI with support from other national poultry associations have achieved significant success in this regard; now, the HPAI vaccine can be manufactured in India and legally imported.

Efforts to ensure farmers can easily obtain the Pollution Board NOC: To address this, the PFI team held meetings with the Haryana government, advocating for the exclusion of the poultry sector from the ‘industry’ category regarding Pollution Board NOCs. We proposed a separate policy for poultry NOCs that requires minimal documentation. PFI Team is hopeful that the Haryana government will soon issue a notification on this matter.

Regarding Market Committee fees for maize and pearl millet (bajra) –Taking this issue seriously, the PFI team held a meeting with the Haryana government. This meeting took place under the chairmanship of our senior colleague and Honorable Cabinet Minister, Shri Mahipal Dhanda Ji, and was attended by the Chief Secretary of Haryana and senior officials from the Mandi Board; other poultry associations also participated alongside the PFI team.

Initiative for biogas plant subsidies for breeder and layer farming – Poultry waste poses a major challenge for our fellow farmers. The cost of installing biogas plants to dispose of this waste is very high; consequently, our team has voiced the farmers’ concerns to the Government of India, specifically requesting a subsidy of ₹1 crore for biogas plants.

Regarding rising Soya DOC prices – Our team conducted a survey to identify the underlying causes and discovered that soya stocks were being hoarded.
In response, we wrote to the PMO and the relevant ministry, urging them to impose an upper limit on soya stockpiling. This intervention halted the rise in soybean prices; while we had anticipated a sharp price surge due to hoarding, the situation was successfully brought under control.

Regarding maize quality and production – Thanks to the sustained efforts of the PFI team, we have observed a significant increase in maize production in the North this year compared to previous years. Through various maize-focused seminars, we have been consistently raising awareness among farmers about maize quality to ensure there is no shortage in the future, given the rising demand.

PFI purchases a plot for a laboratory – 400-square-yard commercial plot has been purchased in Panipat for the PFI laboratory. The project report is ready, and work is set to commence shortly. The laboratory will be completed soon, providing the poultry sector with enhanced technological support. Its primary objective is to offer farmers and the entire poultry sector superior technical support, accurate disease identification, and scientific information.

VIV Select India Exhibition- PFI has enabled even small-scale farmers to experience an international exhibition. Our team brought in thousands of farmers from across the country to provide them with insights into poultry-related technologies, ensuring that advanced technology reaches even the smallest of farmers. Thanks to everyone’s contribution, this exhibition was a resounding success. While we had initially planned to hold this event biennially, given its success and with your continued support, it will now be organized annually—with the next edition scheduled for April 21–23, 2027, at the Yashobhoomi Convention Centre.

Later the Financial Report was presented by Mr. Rahul Khatri, Treasurer, which was unanimously approved by all the PFI Members.

Mr. Sanjeev Gupta, Vice President (HQ) extended Vote of Thanks. Mr. Gupta extended special thanks to all PFI Executive Committee Members, Industry Leaders, Technical Speakers, Delegates Media partners and the entire management team for their dedicated efforts and teamwork.

Technical & Business Sessions – The day featured insightful presentations by leading industry experts and companies: Mr. Uday Singh Bayas, President, Indian Poultry Equipment Manufacturers Association (IPEMA) and Poultry India invited all the delegates present at PFI AGM to attend Poultry India Exhibition being organised at HITEX, Hyderabad on November 25-27, 2026. Later the sponsoring companies gave very interesting and education presentations. This was followed by several educating and informative technical presentations by Team Symbio, Dr. Ajeet Bishnoi, Dr. Harish & Dr. Rahul.

Dr. Rakesh Gupta, General Managet – Technical, Venkateshwara Hatcheries (VH Group) gave very impressive presentation on “Management of Immunosuppression in Broilers” which was very much appreciated by the delegates. There was good interaction after the presentation and Dr. Rakesh Gupta satisfactorily replied to all the questions.

Dr. Vijay Anand, Soy Excellence Center (SEC) India Center Lead, presentation on “Soy as a Continuing Foundation for the Feed Industry” was another engaging segment. The clarity of thoughts and practical approach provided the delegates with several valuable takeaways.

This was followed by presentation of certificates by PFI Core Team to the four toppers of Soy Excellence Center course, a good initiative by US Soybean Export Council.

A high-level panel discussion on “Indigenous Viral Strains for Poultry vaccines: Strengthening Disease Control Through India Specific Solutions” was there which was very well moderated by Dr. Nitin Vasantrao Kurkure and the distinguished panel included Dr. Premanshu Dandapat, Dr. NK Mahajan, Dr. Shirish Nigam, Dr. Sanjay Gavkare and Dr. Gowthaman. Press and Silver & Bronze category sponsors were felicitated for their continuous support, by presenting mementoes. Dr. Jeetendra Verma, Executive Committee Member, Poultry Federation of India, extended Vote of Thanks. The evening concluded with a musical program and cocktail dinner, offering networking opportunities and celebrating unity within the poultry fraternity.

The second day of the 37th Annual General Body Meeting of Poultry Federation of India continued with insightful policy sessions, dignitary addresses and recognition of excellence in the poultry sector.
The day began with welcome address by Mr. Ranpal Dhanda, President, Poultry Federation of India. He emphasised the Federation’s commitment to promoting scientific, profitable and sustainable poultry farming across India. The pace at which India’s poultry sector has grown over the last few decades is truly remarkable. Today, our country ranks among the world’s leading producers of eggs and chicken. According to the ICAR, the poultry sector is making a significant contribution to India’s food and nutritional security. We need to consider Where will India’s poultry sector be in the next ten years? And an even more important question is Are we prepared today for the challenges of the coming decade?

PFI President said “Poultry feed security is an essential part of India’s protein security.” If quality feed is not available at competitive prices, we will be unable to simultaneously achieve farmer profitability, affordable protein for consumers, and global competitiveness for the industry. Today, our scientists have made seeds available that allow us to achieve yields of up to 10–11 tonnes per hectare. I say this based on my own practical experience. For the past three years, I have been cultivating maize on approximately 20 acres, and I am achieving yields of up to 10–11 tonnes per hectare. However, looking at the country as a whole, the average maize productivity here currently stands at only about 3–4 tonnes per hectare. This implies that while we possess quality seeds and scientists have developed superior varieties, the major challenge lies in our inability to deliver these high-quality seeds to every farmer in sufficient quantities. Therefore, our future focus must be on ensuring that the high-quality, high-yield hybrid seeds available to us reach every farm and every farmer. These seeds should be made available at reasonable and subsidized rates so that small and medium-scale farmers can also utilize them.

Mr. Ranpal Dhanda said Our second priority is to transform disease surveillance into an “Early Warning System.” If animal feed represents our first challenge, disease management is our second major hurdle. Modern poultry farming is highly intensive and interconnected. A disease outbreak is not merely a problem for a single farm; it can become an issue for the entire cluster. Therefore, I propose the creation of a National Poultry Disease Surveillance Grid. We should develop an integrated system connecting — Farm → Veterinarian → District Laboratory → State Laboratory → National Reference Laboratory —through a digital network.

Mr. Dhanda added Our third priority is: Vaccination tailored to Indian conditions. India should become a leader in innovation not just a market in the field of poultry vaccines. When Indian science and Indian industry collaborate, Indian solutions can be developed for Indian challenges. Therefore, we urge that the “Indigenous Strain-Based Vaccine Development Programme” be further strengthened. We need to establish a framework wherein ICAR, Veterinary Universities, the Government, the Vaccine Industry, and the Poultry Industry collaborate to conduct research on priority disease.
This was followed by launch of Mission Protein India and its mascot by the Honourable Chief Guest Shri Mahipal Dhanda, Minister of Education, Government of Haryana, along with all the dignitaries on the dias.

Mission Protein India is an initiative by PFI in promoting protein awareness by launching an Instagram page titled “Mission Protein India.” This initiative will provide the general public with information regarding the nutritional value of protein. Our goal is to ensure that accurate, scientific information reaches everyone, enabling people to understand the importance of better nutrition for their health and adopt it into their lifestyles.

Later Mr. Vijay Sardana, Advocate, Supreme Court of India & Techno-Legal Advisor, Poultry Federation of India gave Keynote address. National Poultry Export Mission – On behalf of Poultry Federation of India, it was proposed to Establish a National Poultry Export Mission 2035, with PFI, DAHD, APEDA, MoFPI, Commerce Ministry and relevant state governments working against annual milestones. The Proposed US$10 Billion Export Basket. India should move progressively from bulk shipments to specification-based shipments. The buyer should be able to specify: weight + cut + fat level + packaging + certification + microbiological standard + halal status + traceability. That is how a commodity becomes a differentiated export product. The objective should be to establish Indian processing companies as international suppliers.

Dr. Sunil Neelam, ICAR-Indian Institute of Maize Research gave interesting and highly appreciated presentation on “Strategy to Meet Maize Requirement for Poultry in Changing Scenarios”.

This was followed by address by Mr. Ashok Thakur, Guest of Honour and Director, National Agricultural Cooperative Marketing Federation of India (NAFED). Mr. Thakur offered all the support to poultry sector as it’s creating lot of employment among young generation. His emphasis on strengthening protein security, feed security, farmer welfare and sustainable growth provided important direction for the sector.

The honourable Chief Guest, Shri Mahipal Dhanda, Minister of Education, Government of Haryana addressed the gathering which was truly insightful and inspiring. It was indeed an honour and privilege to hear his valuable thoughts and guidance. The clarity of his vision and his commitment to working closely with industry stakeholders were highly appreciated by all the delegates. The honourable Chief Guest concluded by saying together, let us take Indian Poultry to greater heights and contribute meaningfully to the vision of a Healthy, Prosperous and Viksit Bharat.

Mr. Ricky Thaper, Joint Secretary, delivered The Vote of Thanks by appreciating Hon’ble Chief Guest Shri Mahipal Dhanda Ji, Hon’ble Education Minister, Government of Haryana, and the Guest of Honours for graciously sparing their valuable time to join and bless the 37th AGM with their presence and extended deep appreciation to all 950 plus participants, 111 sponsoring companies, Speakers, Special Invites, Press and all PFI Executive Committee team for their contribution to making the two-day AGM a grand success.

Post lunch there were technical presentations by Mr. Anil Singh Tomar also Mr. Arvindra Singh. The Panel Discussion on “Beyond Maize and Soy-Alternative Feed Ingredients for Efficient and Cost-Effective Poultry Production”

was very nicely Moderatored by Dr. Tarun Shridhar and the panellist included Prof. Dr. PK Shukla, Dr. Ashok Kumar Pattanaik, Dr. Amit Das, Dr. Shiv Kumar Bhardwaj, Dr Nataraja Hulegondi and Dr. Ajay Deshpande. This was followed by the insightful addresses by leading voices from the poultry industry that added tremendous value to the AGM.

The poultry leader’s; Mr. Divya Gulati, Mr. Vasant Kumar, Mr. Madan Mohan Maity and Mr. Bahadur Ali’s perspectives highlighted the sector’s key challenges, emerging opportunities and the need for stronger collaboration among farmers, industry, scientists and policymakers.

Their valuable suggestions on the growth and future of India’s poultry sector reflected a deep understanding of the challenges and opportunities before the industry. The industry leaders brought valuable on-ground experience and practical insights, particularly on feed security, cost competitiveness, farmer sustainability, innovation and the future growth of Indian poultry. Their forward-looking thoughts and constructive suggestions provided meaningful direction for building a more resilient, sustainable and globally competitive poultry industry in India. The rich exchange of ideas truly reflected the strength, unity and collective vision of the poultry fraternity.

Later there was mementoes presentations to Special Guests & Poultry Industry Associations and Super Platinum, Platinum, Diamond & Gold Sponsors. Mr. Rahul Khatri, Treasurer, extended Vote of Thanks. The 37th AGM of the Poultry Federation of India concluded on a highly positive and inspiring note, reaffirming our collective commitment to the growth, sustainability and long-term strength of India’s poultry sector. The discussions, insights and interactions throughout the AGM reinforced one clear message: a strong poultry industry is essential for India’s protein security, farmer prosperity and food security. The evening concluded with a musical program and cocktail dinner, offering networking opportunities and celebrating unity within the poultry fraternity.

However, despite its widespread use, SCC presents several practical challenges, including its highly hygroscopic nature, reduced feed stability, accelerated degradation of certain vitamins, and the formation of trimethylamine (TMA) during microbial metabolism. These limitations, coupled with the industry’s growing focus on efficiency, sustainability, and precision nutrition, have driven the search for more advanced nutritional solutions.

Why Liver Health Matters More Than Ever
In poultry, the liver is the primary site of lipogenesis, accounting for nearly 80–85% of total fatty acid synthesis. Every day, it coordinates the conversion of nutrients into energy, regulates lipid metabolism, synthesizes proteins, and supports numerous physiological functions essential for growth and production. When lipid metabolism becomes impaired, triglycerides accumulate within liver cells, leading to excessive fat deposition, poor feed utilization, reduced growth performance, and an increased risk of fatty liver conditions. These metabolic disturbances can significantly impact both biological efficiency and economic returns. Consequently, maintaining optimal liver function is no longer viewed merely as a health objective; it has become a key driver of productivity and profitability in modern poultry production.

Kolin Plus® : A New Generation Phytogenic Solution
Developed as a scientifically validated phytogenic alternative to synthetic choline chloride, Kolin Plus® represents a new approach to metabolic nutrition. Rather than functioning solely as a nutrient replacement, Kolin Plus® supports liver health and fat metabolism through multiple interconnected biological pathways. Formulated from carefully selected botanical ingredients rich in bioactive compounds, Kolin Plus® works by influencing key metabolic processes involved in lipid synthesis, fat mobilization, fatty acid oxidation, and energy utilization. This multi-pathway mode of action enables the bird to utilize nutrients more efficiently while supporting optimal hepatic function. Backed by transcriptomic research and performance validation studies, Kolin Plus® exemplifies the shift from conventional nutrient supplementation to scientifically driven metabolic optimization.

A Transcriptomic Window into Poultry Metabolism
One of the most exciting developments in animal nutrition has been the application of transcriptomics to understand how dietary interventions influence biological functions.
Transcriptomics enables researchers to evaluate thousands of genes simultaneously and identify the molecular pathways affected by nutritional interventions. To unravel the molecular basis of Kolin Plus® activity, liver gene expression profiling was conducted in broilers challenged with choline-deficient diets. The analysis identified key genes and signaling pathways involved in lipid synthesis, mobilization, oxidation, and overall hepatic lipid regulation. The gene expression patterns were studied for four groups normal diet: normal, choline chloride deficient, Kolin Plus®, and CCL using microarray on day 42. The hierarchical cluster analysis was carried out on 12,614 differentially expressed genes (DEGs) with a similar expression.

Regulating Fat Synthesis at Its Source
One of the most significant findings from transcriptomic research was the modulation of genes involved in hepatic fat synthesis. Key genes associated with lipogenesis—including PPARG, ACACA, ACLY, and LIPC were regulated in a manner that supports healthier lipid metabolism. These genes play important roles in: Fatty acid synthesis, Triglyceride accumulation, Lipid storage, Hepatic lipid regulation. By influencing these pathways, Kolin Plus® helps create a metabolic environment that favours efficient nutrient utilization while reducing excessive fat deposition within the liver. (Table 1, Fig1)

Figure 1. Effect of KP on gene expression related to de novo lipogenesis.
Activating the Fat-Burning Machinery
While reducing fat synthesis is important, optimal metabolic health also requires efficient utilization of stored fats. The transcriptomic analysis revealed enhanced expression of genes associated with fatty acid oxidation, including:  CPT1A, PPARGC1A, HADHB, PNPLA2
These genes are directly involved in transporting fatty acids into mitochondria and converting them into usable energy through β-oxidation. In practical terms, this means the bird becomes more efficient at utilizing dietary energy rather than storing it as excess fat.
Further studies demonstrated increased circulating levels of L-carnitine in supplemented birds.
L-carnitine serves as the transport system that carries long-chain fatty acids into mitochondria, where they are oxidized to generate energy. Improved L-carnitine status has been associated with:
– Enhanced fat utilization
– Reduced carcass fat deposition
– Improved energy efficiency
– Better production performance
This finding provides an important physiological link between molecular changes and measurable production outcomes. ((Table 1, Fig 2)

Fig 2: Effect of KP on catabolism of lipids (lipolysis and beta-oxidation of fatty acids.

From Molecular Science to Farm Performance
The true value of any nutritional intervention lies in its ability to improve on-farm performance.

Research Studies has demonstrated benefits including:
– Improved body weight gain
– Better feed conversion ratio (FCR)
– Reduced fat accretion
– Enhanced livability
– Improved European Production Index (EPI)
These improvements reflect the practical impact of optimizing lipid metabolism and liver function.  Rather than acting as a simple replacement for choline, this approach supports multiple interconnected pathways that collectively improve metabolic efficiency.

Sustainability Through Better Metabolism
Modern poultry production increasingly demands solutions that are not only effective but also sustainable. Improved lipid utilization means more dietary energy is directed toward productive purposes rather than being lost through inefficient metabolism.
This can contribute to:
– Better feed efficiency
– Lower resource utilization
– Reduced environmental impact
– Improved economic sustainability
As the industry continues to pursue precision nutrition and sustainable production systems, metabolic optimization will play an increasingly important role.

Conclusion
The future of poultry nutrition is moving beyond simple nutrient supplementation toward a deeper understanding of how nutrition influences biological systems. Advances in transcriptomics and nutrigenomics have shown that phytogenic technologies can regulate gene expression, optimize lipid metabolism, support mitochondrial function, and enhance metabolic efficiency.
By influencing key pathways involved in fat synthesis, lipid transport, and fatty acid oxidation, these next-generation nutritional solutions help improve liver health, nutrient utilization, and production performance. Kolin Plus®, backed by transcriptomic validation and performance studies, exemplifies this scientific approach by supporting metabolic health through multiple biological pathways rather than functioning as a conventional choline replacement alone.
As the poultry industry continues to focus on efficiency, profitability, and sustainability, scientifically validated phytogenic solutions such as Kolin Plus® are redefining metabolic management and shaping the future of precision poultry nutrition.

Introduction

Why it matters in modern poultry production
– Rapid multiplication of Eimeria can produce substantial intestinal injury within a short period.
– Subclinical coccidiosis may reduce feed efficiency, growth and flock uniformity without dramatic clinical signs.
– High oocyst contamination of litter increases exposure and repeated infection pressure.
– Effective control requires attention to parasite biology, farm management and appropriate anticoccidial programmes.

Etiology
Seven major Eimeria species are recognized in chickens. E. acervulina and E. maxima are frequently encountered, while E. tenella is particularly pathogenic and associated with severe caecal disease and haemorrhage (Yaqub et al., 2023). Species differ in preferred intestinal sites, lesion patterns and pathogenicity.

Transmission
The principal route is faecal–oral transmission. Birds ingest sporulated oocysts from contaminated litter, feed, water, equipment or the environment. Moisture, oxygen and suitable temperature favour sporulation, allowing infective oocysts to accumulate and maintain the infection cycle (Pal et al., 2023).
Life Cycle of EIMERIA

Ingestion of sporulated oocysts → release of sporozoites → epithelial invasion → multiplication → gamete formation → oocyst formation → faecal shedding → environmental sporulation.

Clinical Signs
Severity depends on Eimeria species, infective dose, bird age, immunity and environmental management. Signs include reduced feed intake, depression, ruffled feathers, drooping wings, enteritis, diarrhoea or dysentery, poor growth and increased mortality in severe cases (Pal et al., 2023).
– Reduced body-weight gain and flock uniformity
– Poor feed conversion and production performance
– Diarrhoea or blood-stained droppings in severe infections
– Dehydration, weakness and depression
– Mortality when tissue damage and blood loss are extensive
Species-specific sites

Post-Mortem Lesions
Post-mortem examination helps identify likely Eimeria species and estimate the distribution and severity of intestinal damage. Lesion patterns should be interpreted with clinical findings, litter condition, performance data and, where appropriate, laboratory diagnosis (Pal et al., 2023; Yaqub et al., 2023).

Key lesion patterns

Prevention and Control
Effective control integrates anticoccidial programmes with litter management, hygiene, stocking-density control, ventilation and sound flock management. Continuous or inappropriate use of a single anticoccidial can contribute to reduced efficacy and resistance selection; rotation, shuttle programmes, combinations and vaccination are among approaches used for longer-term control (Usman et al., 2011; Chapman, 2017; Noack et al., 2019).

Anticoccidial programmes
– Rotation changes the active ingredient or mode of action between production cycles.
– Shuttle programmes use different anticoccidial strategies during different feed phases.
– Combination programmes can broaden anticoccidial activity and may help address reduced sensitivity when appropriately designed (Chapman & Rathinam, 2022).
– Vaccination can provide controlled exposure to selected Eimeria strains and support protective immunity.

Ionophore vs Chemical

Combination programmes
Combining compatible anticoccidial activities can broaden control and reduce dependence on a single mode of action. Programme selection should consider disease pressure, previous anticoccidial history, susceptibility patterns, compatibility and label requirements (Chapman & Rathinam, 2022).

STALLEN’S DUAL APPROACH TO COCCIDIOSIS CONTROL
Stallen South Asia offers a dual approach to coccidiosis management with Manacox Plus, bringing together ionophore and chemical anticoccidial activity in one formulation. This approach is designed to support practical, structured coccidiosis-control programmes while reducing dependence on a single mode of action.

MANACOX PLUS
Manacox Plus is a dual-active anticoccidial formulation combining an ionophore and a chemical anticoccidial. It contains Monensin Sodium 8% + Nicarbazin 8% for practical coccidiosis prevention programmes in broilers.
Key Product Points

WHY A DUAL APPROACH
Using monensin sodium together with nicarbazin brings ionophore and chemical anticoccidial activity into one formulation. This can fit structured prevention programmes where the objective is effective control without unnecessary reliance on a single mode of action. Use should follow the approved label and veterinary guidance.
Practical use
– Use within a planned farm coccidiosis-control programme.
– Maintain good litter quality, ventilation, stocking density and drinker management.
– Review anticoccidial history and flock response when planning future programmes.
– Follow approved dose, withdrawal period and compatibility instructions.

References are available on request.

Introduction

Gut: The First Line of Immune Defence
The intestinal defence system consists of several interconnected components, including the mucus layer, intestinal epithelial cells, tight junctions, antimicrobial substances, gut microbiota and gut-associated lymphoid tissue (GALT).

The epithelial cells form a physical barrier between the intestinal contents and the internal tissues. Tight-junction proteins such as occludin, claudins and ZO-1 regulate the movement of substances between epithelial cells. The mucus layer provides an additional protective environment, while immune cells located within and beneath the intestinal mucosa continuously monitor microbial and dietary antigens.
Thus, the intestine acts as both a selective absorption system and an immune surveillance system.

Gut Microbiota and Immune Development
The intestinal tract contains a complex microbial ecosystem. A balanced microbial population can contribute to pathogen exclusion, production of microbial metabolites, maintenance of intestinal integrity and modulation of host immune responses.
Beneficial microorganisms and their metabolites communicate with intestinal epithelial cells and immune cells. Among these metabolites, short-chain fatty acids (SCFAs) such as acetate, propionate and butyrate are particularly important because they can influence epithelial health, immune-cell activity and inflammatory responses. Therefore, gut microbiota and immunity have a bidirectional relationship. A healthy microbiota supports a healthy intestinal barrier and balanced immune signalling. At the same time, the immune system regulates microbial populations and helps maintain intestinal homeostasis.
What Happens When Gut Health Is Compromised?
Commercial poultry are exposed to several factors capable of disturbing gut integrity, including coccidiosis, bacterial pathogens, mycotoxins, heat stress, poor water quality, nutritional imbalance and dysbiosis.

A compromised gut can result in epithelial damage, disruption of tight junctions, increased intestinal permeability, inflammation and oxidative stress, altered immune response and reduced performance. This process is sometimes described as increased “intestinal permeability” or “leaky gut.”

When intestinal integrity is compromised, nutrients may not be utilized efficiently and microbial products can interact more extensively with host immune mechanisms. The bird may consequently spend additional nutrients and metabolic resources on inflammation and tissue repair rather than growth or egg production.

Coccidiosis, Mycotoxins and Heat Stress

Coccidiosis is a classic example of the gut–immune relationship. Eimeria infection damages intestinal epithelial cells, alters intestinal morphology and stimulates an inflammatory and immune response. Consequently, coccidiosis control is not only a parasite-management issue but also a gut health, nutrition and immune-management issue.

Similarly, mycotoxins can affect intestinal integrity, oxidative status, microbial balance and immune function. Their impact may therefore extend beyond the feed itself to the overall gut–immune axis.

Heat stress is particularly important in tropical poultry production. Heat stress can alter feed intake, intestinal physiology, microbial balance and barrier integrity, potentially increasing inflammatory and oxidative stress. Maintaining gut integrity during heat stress is therefore an important component of maintaining flock resilience.

Gut Health and Vaccine Response
An effective vaccination program depends on the bird’s ability to recognize antigens and develop appropriate humoral and cellular immune responses. This requires adequate availability of energy, amino acids, vitamins, minerals and antioxidants. Therefore, gut health indirectly supports the nutritional foundation required for immune responses. A healthy intestine facilitates nutrient digestion and absorption, while intestinal inflammation or damage can increase nutrient requirements for tissue repair and immune activity. It is important, however, to recognize that good gut health alone does not guarantee vaccine success. Vaccine quality, administration, maternal immunity, biosecurity, disease pressure, nutrition and environmental conditions also influence the final immune response.

Nutritional Support for the Gut–Immune Axis
Nutrition is one of the most important tools for supporting the gut–immune relationship. Zinc contributes to epithelial integrity, cellular proliferation, enzyme activity and immune-cell function. Selenium is an important component of antioxidant defence systems and supports cellular protection and immune function. Vitamins A and E also contribute to mucosal integrity, antioxidant protection and immune responses.
Nutritional interventions such as probiotics, prebiotics, postbiotics, organic acids, enzymes, yeast-derived products, MOS and β-glucans may be used as part of integrated gut-health programs. MOS can support gut health through microbial interactions and pathogen-exclusion mechanisms, while β-glucans can interact with innate immune pathways and influence immune-cell activity. However, responses depend on product source, structure, dose, bird age, diet and challenge conditions; therefore, these products should be evaluated based on scientific evidence and field performance rather than assuming that all products have identical effects.

Practical Approach for Commercial Poultry
A successful gut-health program should not depend on a single feed additive. It should combine:
– High-quality and properly stored feed
– Regular mycotoxin monitoring and management
– Good drinking-water quality and sanitation
– Effective coccidiosis control
– Appropriate vaccination and biosecurity
– Heat-stress management
– Balanced amino acid, vitamin and mineral nutrition
– Appropriate use of probiotics, prebiotics/postbiotics and other gut-health products
– Monitoring of litter quality, feed intake, FCR, mortality and flock uniformity

Conclusion
The gut and immune system should be viewed as two interconnected components of the same biological defence network. A healthy intestinal microbiota, intact epithelial barrier and properly functioning GALT provide the foundation for balanced immune development and response. For commercial poultry, the concept is simple: “Protect the gut to support immunity, and support immunity to maintain flock resilience.”
Gut health is therefore not only about digestion and FCR. It is closely connected with nutrient utilization, immune development, disease resistance, vaccine responsiveness and ultimately flock productivity.
The future of poultry nutrition will increasingly focus on managing the gut–microbiota–immune axis through integrated nutrition, health and farm-management strategies rather than addressing individual problems in isolation.

The meeting commenced with an introductory address by Mr. Deepak Khosla, General Manager (Marketing), who welcomed the participants and highlighted the company’s commitment to delivering science-based solutions for the poultry industry.

Dr. Prakash Reddy, DGM (Technical), delivered a currently relevant and focused presentation on “Hatchery Vaccines and Vaccination: Catching the Future”. He emphasized on the emergence of pathogens which are critical for designing effective control strategies because it reveals key vulnerabilities, transmission dynamics (vertical), and potential immune evasion mechanisms. Highlighted the emerging vaccine technologies opening new fields of possibilities for disease control and disease management, which include genotype based vaccines, vector vaccines, immune complex vaccine etc. The novel vaccine technologies would likely impose completely novel immune pressure or selection for resistance with enhanced immunosuppression and changes in patterns of antigenic variation, tissue tropism, and invasion pathways, so should be selective. Lastly, he updated the Innovative hatchery vaccination methods adapted in India for mass administration with speed and accuracy with ease of adaptation of semi-automated subcutaneous vaccination, spray vaccination etc. in day old chicks with a check on vaccinal reactions, errors and miss outs.

The second session, “Improving Broiler Performance through Effective Water Sanitation and Precise Medication Dosing,” was presented by Dr. Datta Kulkarni, DGM (Technical). He discussed how good water quality, effective sanitation, and accurate medication dosing can help enhance broiler health, performance, and farm profitability.

The programme concluded with valuable remarks from Mr. H. S. Padda, DGM, (Marketing), who underlined the importance of adopting scientific and practical approaches to address emerging poultry health challenges. Mr. Shashi Bhushan, AGM, (Marketing), delivered the vote of thanks and expressed gratitude to the speakers and participants for making the meeting informative and successful.

The technical meeting reaffirmed Ventri Biologicals’ commitment to advancing poultry health through knowledge sharing, innovation, and effective field-level solutions.

Yet despite the widespread use of organic trace minerals (OTMs), one important misconception continues to exist in the industry: that all organic trace minerals are the same.

Looking Beyond Inclusion Levels
When evaluating trace mineral programs, discussions often focus on inclusion rates, mineral concentration, and cost per ton of feed.

However, the true value of a trace mineral is not determined simply by how much is added to a formulation. Rather, it is determined by how much of that mineral is available for absorption and utilization by the bird. This distinction becomes increasingly important in modern poultry production.

Many producers experiencing challenges like, inconsistent performance, reduced meat quality, or variability in the flock focus on nutrient inclusion. Yet nutrients can only contribute to biological functions if they successfully reach the absorption sites where they are needed.

As poultry genetics continue to advance, nutritional efficiency has become just as important as nutritional adequacy. This shift is causing nutritionists to move beyond a simple question of: “How much mineral is in the feed?” to a more important question: “How much mineral is actually available to the bird?”

Understanding the Challenge: Mineral Antagonism
Trace minerals perform important functions throughout the bird’s body. Zinc, copper, and manganese act as cofactors for numerous enzymes involved in bone formation, connective tissue development, collagen synthesis, skin integrity, antioxidant defense, and immune function.

However, the digestive tract is a highly complex environment. As minerals move through digestion, they encounter changes in pH and interactions with dietary compounds such as phytate, fiber components, and even other minerals. These interactions can reduce mineral availability before absorption occurs.

This phenomenon, referred to as mineral antagonism, helps explain why increasing mineral inclusion does not always result in improved mineral utilization. Simply feeding more minerals does not necessarily mean the bird receives more minerals. In many situations, the challenge is not supply. The challenge is bioavailability.

Dietary antagonisms can reduce mineral availability before absorption occurs, limiting nutrient utilization despite adequate inclusion levels

Organic Trace Minerals: A Category, Not a Chemistry
To help improve mineral bio-availability, the industry increasingly adopted organic trace minerals. However, the term “organic trace mineral” can create confusion. Some assume that all OTMs provide similar benefits because they belong to the same category. In reality, organic trace minerals represent a broad group of products that may differ substantially in:
· Ligand type
· Ligand-to-mineral ratio
· Molecular structure
· Bonding characteristics
· Electrical charge of the molecule
· Stability in Upper Digestive Tract
These differences influence how minerals behave in the gastrointestinal tract and how effectively they remain available for absorption. In other words, two products may both be labelled as organic trace minerals while functioning very differently inside the bird.

Why Chelation Matters
Among organic trace minerals, one class stands out from the others: bis-chelates. The word chelate originates from the Greek word chela, meaning crab claw or pincer. Similar to two crabs holding a metal securely giving it the maximum protection a Chelate forms when a ligand connects to a metal atom at more than two points. A 2 five member rings connected to the metal with two points of contact is the most stable complex found in nature. This structure helps provide protection compared with less defined mineral associations. However, not all organic trace minerals are true chelates. True chelates require a neutral charge to protect the mineral and enhance stability. Not all organic trace minerals (OTMs) provide a neutral charge; therefore, not all OTMs are true chelates. Some products are better described as complexes, proteinates, or other association forms. While they are still classified as organic trace minerals, they can differ significantly in chemical stability and behavior during digestion. The degree of protection provided by the mineral structure ultimately determines how vulnerable the mineral may be to antagonistic interactions.
Differences exist among chelates, too. There are chelates where one ligand is bound to the metal and then there are bis-chelates where two ligands are bound, creating a neutral charge and making the molecule less susceptible to antagonism. (see image)

Why Molecular Structure Matters
Research continues to demonstrate that mineral structure influences stability and bio-availability. When minerals dissociate during digestion, they become charged ions that are more likely to interact with negatively charged compounds such as phytate, fiber complexes and other minerals. These interactions can reduce availability before absorption occurs.

For this reason, increasing attention is being given to mineral structures specifically designed to maintain stability throughout digestion. One such approach is bis-chelation technology.

Bis-chelated trace minerals are characterized by a defined molecular structure consisting of one mineral ion bound to two ligands, creating two stable chelate rings. This unique architecture helps maintain structural integrity while moving through the digestive tract.
An equally important feature is their neutral molecular charge. Because neutrally charged molecules are less likely to participate in unwanted interactions, the structure helps protect the mineral, reducing opportunities for antagonism and supporting mineral availability until absorption occurs.

Bis-chelated trace minerals feature a defined molecular structure designed to support stability and mineral availability during digestion.

The Future of Trace Mineral Nutrition
As poultry production evolves, mineral nutrition must evolve with it. The industry’s next opportunity may not come from increasing mineral inclusion rates but from improving how effectively minerals are utilized by the bird. This requires looking beyond product categories and focusing on the scientific characteristics that influence mineral availability. Organic trace minerals can provide significant advantages over traditional inorganic sources. However, not all organic trace minerals are created equal. Their molecular structure matters. Their stability matters. And ultimately, their ability to deliver minerals to the animal matters.

As nutritionists continue searching for ways to improve performance consistency, skeletal integrity, meat quality, and return on investment, bis-chelated trace minerals are an increasingly important technology because they combine defined structure, enhanced stability, and optimized bioavailability into a scientifically designed mineral solution.

Contact your local NOVUS representative to learn more about bis-chelated trace minerals from the company that brought the technology to the animal agriculture industry over 20 years ago.

FERMNUTRAL: A POSTBIOTIC INNOVATION TO MAXIMIZE GUT HEALTH AND EFFICIENCY IN POULTRY PRODUCTION

Gut Health: The Key to Modern Poultry Production
The expression of the genetic potential of poultry largely depends on intestinal health. The gastrointestinal tract houses nearly 70% of the immune cells and constitutes the primary barrier against enteric pathogens. However, during the early stages of life, immune immaturity increases susceptibility to infections and microbiota imbalances, particularly under intensive production systems.

Traditionally, antibiotic growth promoters (AGPs) have been used to improve productive performance and reduce health-related challenges. However, their continuous use has been associated with antimicrobial resistance, intestinal dysbiosis, and concerns regarding food safety and public health.

In this context, postbiotics have emerged as a sustainable alternative. They are defined as preparations of inanimate microorganisms and/or their bioactive components, including short-chain fatty acids, bacteriocins, exopolysaccharides, peptides, and cell

wall fragments. Unlike probiotics, postbiotics offer greater stability, safety, and consistency, making them an effective alternative to AGPs (Zhong et al., 2022).

Postbiotics vs. Probiotics: A Real Competitive Advantage
The probiotics most commonly used in poultry production, such as Lactobacillus spp. and spore-forming Bacillus spp., present certain limitations when compared with postbiotics.

Lactobacillus species are heat-sensitive microorganisms; therefore, their survival during feed pelleting and storage may be compromised. In addition, factors such as chlorination of drinking water can reduce their viability and, consequently, their biological efficacy.

In contrast, Bacillus spp. exhibit high resistance to elevated temperatures due to spore formation. However, their beneficial effects may depend on successful intestinal germination and on the physiological and microbiological conditions of the host. Furthermore, these bacteria do not permanently colonize the gastrointestinal tract, meaning that their biological impact may depend on continuous administration through feed or drinking water.

Postbiotics exhibit high stability during feed processing and storage, as well as in chlorinated drinking water, because they do not rely on cell viability. Moreover, their bioactive compounds can exert their effects immediately upon ingestion, without requiring germination or intestinal colonization. This allows for a faster, more reproducible, and more consistent response (De Marco et al., 2018).

FermNutral: Bioactive Profile of a Full-Spectrum Postbiotic
FermNutral is a postbiotic developed and manufactured by CPBIO through the controlled biological fermentation of the Clostridium butyricum CPBIO3000 strain using natural raw materials. (Figure1)

The product is supplied as granules with demonstrated stability at temperatures exceeding 80°C (simulating the feed pelleting process). The recommended inclusion rate for poultry is 300–500 g/t of feed. FermNutral is produced under FAMI-QS, FDA-cGMP, and ISO 9001/14001/18001 certifications, which have been maintained since 2001.

FermNutral contains a diverse range of bioactive compounds generated during the fermentation process, including teichoic acids, lipoteichoic acids, butyricin, antimicrobial peptides, and exopolysaccharides.

Within its short-chain fatty acid (SCFA) fraction, butyric acid represents approximately 40% of the total SCFAs. Other SCFAs are present at lower concentrations, including acetic acid (21.6 mg/kg) and propionic acid (81.6 mg/kg).
The vitamin fraction includes vitamin E (13.9 IU/kg), vitamin B1 (17.2 mg/kg), vitamin B2 (5.08 mg/kg), vitamin B5 (57.3 mg/kg), vitamin B6 (98.3 mg/kg), vitamin B12 (0.34 mg/kg), folic acid (30.9 mg/kg), and vitamin K3 (1.97 mg/kg). The mineral profile provides calcium (15.2%), total phosphorus (0.76%), iron (760 mg/kg), zinc (42 mg/kg), magnesium (3,600 mg/kg), and chromium (11.67 mg/kg). Additionally, FermNutral contains 17 amino acids, including glutamic acid (1.37%), alanine (0.59%), valine (0.46%), leucine (0.50%), and lysine (0.29%). Altogether all amino acids are between 10-12% in product.

This unique combination of bioactive metabolites, nutrients, vitamins, minerals, and amino acids supports intestinal integrity, microbial balance, immune function, and productive performance in poultry.

Figure 1: A postbiotic product derived from biological fermentation of Clostridium butyricum CPBIO3000 using natural raw materials

FermNutral: Bioactive Compounds
FermNutral contains a wide range of bioactive compounds generated during the fermentation process, with butyric acid being the predominant short-chain fatty acid (SCFA), representing approximately 40% of the product. Butyrate serves as a major energy source for enterocytes and promotes epithelial renewal, mucin synthesis, and the expression of tight junction proteins. These effects contribute to maintaining intestinal barrier integrity and reducing intestinal permeability.
In addition, butyrate exhibits immunomodulatory and anti-inflammatory properties through its ability to regulate epigenetic processes, promote goblet cell differentiation, and stimulate the activation of regulatory T lymphocytes. It may also enhance intestinal serotonin release, which has been associated with the gut-brain axis and productive performance. Acetic and propionic acids complement these effects by regulating the intestinal environment and inhibiting undesirable microorganisms.

FermNutral also provides teichoic acids and lipoteichoic acids, which are recognized by Toll-like receptor 2 (TLR-2) on the intestinal mucosa. These components modulate both innate and adaptive immune responses, promoting a balance between immune defense and tolerance while helping to control intestinal inflammation (Pasquina et al., 2013; Muhammad et al., 2021).

Furthermore, FermNutral supplies butyricin (a bacteriocin), bioactive peptides, and antimicrobial peptides produced during fermentation, which contribute to the control of undesirable microorganisms and the modulation of intestinal microbiota. Exopolysaccharides are also present and have been reported to stimulate secretory IgA production and strengthen the mucosal barrier. In addition, the product’s vitamin and mineral profile acts synergistically to support immune function, antioxidant status, intestinal integrity, and productive performance.

FermNutral in poultry production
Several experiments conducted in China and Thailand have demonstrated the efficacy of FermNutral in poultry production. In a study at Guizhou University (China) comparing a control diet with additives such as FermNutral, Clostridium butyricum, protected sodium butyrate, and tributyrin in broiler chickens, the postbiotic (FermNutral) was confirmed to improve weight gain (+13%) and reduce feed conversion ratio (-11.68%) compared with the control and other experimental treatments.

In addition, another experiment carried out in a commercial broiler farm in China found that FermNutral reduced the feed conversion ratio (1.73 vs 1.77) and improved viability (+1.94) and the European Production Efficiency Factor (EPEF; 338.70 vs 315.30) in relation to the control diet.
Likewise, in a commercial broiler farm in Thailand, the use of FermNutral increased weight gain (+4.2%) and EPEF (+11.70%) and reduced feed conversion ratio (-7.69%). Furthermore, other trials conducted at Guizhou University (China) showed that FermNutral increased villus height in the duodenum (+9%), jejunum (+4%), and ileum (+8%), and improved the villus height to crypt depth ratio (V/C) in the duodenum (6.92 vs 6.27) and jejunum (5.71 vs 5.04).

Figure 3 : FermNutral effect on Immunoglobulins

Additional results from this experiment reported that FermNutral decreased the population of Escherichia coli in the duodenum (0.014 vs 0.234) and jejunum (0.0004 vs 0.013). Moreover, it promoted the growth of Lactobacillus in different intestinal segments, as determined by the relative abundance of microorganisms through 16S rDNA sequencing. (Figure 2) Finally, the inclusion of FermNutral in the diet improved the concentration of IgA (+13%), IgG (+19%), and IgM (+24%) compared with the control diet. (Figure 3)

Figure 2 : 16S rDNA sequencing to determine relative abundance of microorganisms in Poultry Intestine

Other trials conducted on a commercial farm in China with 48-week-old laying hens showed that FermNutral improved laying rate (+1.4) and shell thickness (+0.05 mm), while reducing feed conversion ratio (-0.06) and broken eggs (-2.6%), without affecting other productive performance parameters.

Likewise, in an experiment carried out at Henan Agricultural University, China, using 50-week-old laying hens, FermNutral increased egg weight (61.63 vs 59.77 vs g) and improved feed conversion ratio (2.08 vs 2.11 vs), while reducing dirty eggs (0.17 vs 0.45 %), broken eggs (0.32 vs 0.47 %), and unfit eggs (0.15 vs 0.28 %). These results demonstrate that FermNutral is an innovative and differentiated alternative within the new generation of postbiotics.

References
De Marco S, et al. (2018). Probiotic cell-free supernatants exhibit anti-inflammatory and antioxidant activity. Evidence-Based Complementary and Alternative Medicine.
Liu H, et al. (2023). Postbiotics modulate gut health and laying performance in laying hens. Animal Nutrition, 14, 244–256.
Muhammad I, et al. (2021). Lipoteichoic acid from Bacillus subtilis improves immune function of broiler chickens. Antioxidants, 10(9), 1414.
Pasquina LW, et al. (2013). Teichoic acid biosynthesis as an antibiotic target. Current Opinion in Microbiology, 16(5), 531–537.
Zhong R, et al. (2022). Gut microbiota and its interactions with postbiotics in animal production. Frontiers in Microbiology, 13, 831495.
About CPBIO – A Global Biotech Company, Based on the global practice of Charoen Pokphand Group in the agricultural, animal husbandry and food industry chain, CPBIO has extensively and deeply participated in the health cause of animals, the earth and human beings with the thinking of the whole industry chain. Organizations and individuals in large-scale validated products and solutions.

About CPBIO – A Global Biotech Company, Based on the global practice of Charoen Pokphand Group in the agricultural, animal husbandry and food industry chain, CPBIO has extensively and deeply participated in the health cause of animals, the earth and human beings with the thinking of the whole industry chain. Organizations and individuals in large-scale validated products and solutions.

The 27th edition of World Poultry Congress (WPC) 2026 organised by the World’s Poultry Science Association (WPSA) at the Metro Toronto Convention Centre, Toronto, Canada, from July 13–17, 2026 was recognised as the world’s premier gathering for poultry science and technology, WPC 2026 had brought together a good delegates comprising poultry scientists, researchers, academicians, veterinarians, industry leaders, production specialists, policymakers, and students from more than 85 countries. The congress served as an exceptional platform for exchanging knowledge, showcasing cutting-edge innovations and strengthening international collaborations that will shape the future of the poultry industry.

The scientific and technical program covered a wide spectrum of critical topics including genetics and breeding, poultry nutrition, health and disease prevention, animal welfare, sustainability, precision production technologies, processing innovations and global food security. At a time when the poultry sector is addressing evolving challenges related to disease management, climate resilience, sustainability and feeding a growing global population, forums like WPC continue to play a pivotal role in driving science-based solutions and technological advancement.

Held once every four years under the auspices of the World’s Poultry Science Association (WPSA), the World Poultry Congress remains one of the most influential international platforms dedicated to advancing poultry science and industry worldwide.

The success of WPC 2026 was made possible through the support of leading global organizations, including Elanco and Cargill Animal Nutrition and Health as Platinum Sponsors, Merck Animal Health and Zoetis as Gold Sponsors, Anitox, Evonik, Novus International, Inc, Huvepharma; Trouw Nutrition, Novonesis Animal Health and Nutrition, Nor-Feed, Insighter Biotechnology, JBT Marel, Adisseo, Jefo Biotechnology, Olmix Biotechnology Research and Vtagro as Bronze Sponsors and was supported by Jamesway, Hendrix Genetics Layers, Egg Farmers of Canada, Chicken Farmers of Canada, Turkey Farmers of Canada, Canadian Hatching Egg Producers, Alternative Design Manufacturing and Suply, Inc., Allix3, US-RSPE, JRS Livestock Applications and Hy-line International. WPC-2016 was further supported by esteemed media partners including Canadian Poultry Magazine, WATT Poultry, Agri Insight, Poultry Creations, Gulf Poultry, Modern Poultry, and aviNews International.

The exhibitors displayed their promotional material in Exhibit Hall and the seminars / presentations were in various session rooms. The poster and oral presentation sessions represented the cutting edge of global poultry research. Forty plus speakers from six continents, hundreds of abstracts across every major area of poultry science. During World Poultry Congress 2026, it was my privilege to meet distinguished poultry leaders, scientists, researchers, innovators and industry colleagues from around the world and explored new opportunities for collaboration that will contribute to the sustainable growth and future of the global poultry sector.

My sincere congratulations to the World’s Poultry Science Association (WPSA), the organising committee, sponsors, exhibitors, and everyone who worked tirelessly to make WPC 2026 an outstanding success.As one memorable chapter comes to an end, we now look forward to the 28th World Poultry Congress, which will be held in Tokyo, Japan, from July 21–25, 2030.

Every day, a broiler’s intestine processes several times its body weight in feed and water, encounters billions of microorganisms, responds to environmental stress, and continuously decides what enters the body and what remains outside.

In many ways, the gut functions as a customs checkpoint, security system, digestive factory, and immune headquarters—all at the same time.

In fact, nearly 70% of the bird’s immune cells are associated with the gastrointestinal tract, making it a key player in both health and performance. The remarkable aspect is that when the gut is functioning well, nobody notices it. When it begins to fail, everybody notices the consequences.

The Modern Poultry Bird: Built for Speed
Today’s broiler is a biological marvel. Through decades of genetic selection, modern birds reach market weight faster and more efficiently than ever before.
However, this achievement comes with a hidden challenge.

The digestive tract has become one of the most critical performance-limiting organs in poultry production. Every gram of feed must be digested, absorbed, and converted into muscle within an increasingly compressed production cycle.

Twenty years ago, a small reduction in nutrient absorption might have gone unnoticed. Today, even minor intestinal inefficiencies can translate into measurable losses in body weight gain, feed conversion ratio, and profitability. Modern birds can no longer afford a lazy gut.

The Gut Is Constantly Making Decisions
Traditionally, we think of the intestine as a nutrient absorption organ.
In reality, the gut is making thousands of biological decisions every second.

– Should nutrients support growth or immunity?
– Should a microorganism be tolerated or eliminated?
– Should energy be invested in production or defense?
– Should the intestinal barrier remain open for absorption or tighten to prevent invasion?

These microscopic decisions ultimately determine flock performance.
In many ways, poultry production is not simply about feeding birds—it is about influencing the decisions being made within the gut.

The Hidden Cost of Inflammation
One of the most important concepts emerging in poultry science is that inflammation carries a nutritional cost.
Whenever the intestine encounters stress from pathogens, mycotoxins, heat, poor litter quality, or microbial imbalance, the immune system becomes activated.
The immune response is essential for survival, but it is expensive.
Energy that could support growth is redirected toward immune activity.
Amino acids that could build muscle are utilized to produce immune proteins and inflammatory mediators.
Vitamins and minerals become involved in tissue repair and antioxidant defense.
The bird continues eating, yet a significant proportion of nutrients may no longer be contributing to production.
This phenomenon is often referred to as the “hidden feed cost” of inflammation.

The Silent Performance Thief
One of the greatest misconceptions in poultry production is that intestinal problems always produce visible symptoms.
– Not necessarily.
– Many flocks show normal feed intake, acceptable mortality, and no obvious disease outbreaks. Yet they consistently fail to achieve target performance.
– A slight reduction in nutrient absorption.
– A minor microbial imbalance.
– A low level of intestinal inflammation.
– A subtle increase in intestinal permeability.
Individually these changes may appear insignificant. Collectively they can result in substantial economic losses. This is why gut health is increasingly viewed not as a disease issue but as a performance issue.

The Microbial Workforce Inside Every Bird
Perhaps the most fascinating discovery in recent years is the realization that birds are never truly alone.
The digestive tract contains trillions of microorganisms collectively known as the gut microbiome.
These microbes help digest feed ingredients, produce beneficial metabolites, support intestinal development, influence immune responses, and compete with harmful bacteria.
Some scientists now describe the microbiome as an additional organ because of its profound influence on bird health.
This raises an interesting question:
Are we feeding the bird, or are we feeding its microbiome?
The answer is both.
The future of poultry nutrition may depend as much on managing microbial populations as on balancing nutrients.

Heat Stress: The Gut’s Greatest Enemy
In many poultry-producing regions, heat stress has become one of the most significant challenges affecting gut health.
High environmental temperatures reduce blood flow to the intestine, increase oxidative stress, and compromise intestinal barrier integrity.
As a result, harmful bacterial toxins can cross the intestinal wall and trigger inflammation.
Often the first casualty of heat stress is not growth—it is gut integrity.
This may explain why heat-stressed flocks frequently show poorer FCR, increased wet litter, reduced nutrient utilization, and greater disease susceptibility.
As global temperatures continue to rise, protecting gut health during periods of heat stress will become increasingly important.

The Gut in the Antibiotic-Free Era
The poultry industry is rapidly transitioning toward antibiotic-free and reduced-antibiotic production systems.
While this shift addresses consumer concerns and regulatory requirements, it has also increased attention on intestinal health.
Without routine antibiotic growth promoters, producers must rely on alternative strategies to maintain gut stability.
Probiotics, prebiotics, β-glucans, mannan oligosaccharides (MOS), organic acids, phytogenic compounds, and postbiotics are increasingly being used to support intestinal resilience and microbial balance.
The focus is shifting from killing pathogens to creating an intestinal environment where beneficial microbes and the host can thrive together.

More Birds or More Protein?
The global poultry industry is not being asked to produce more birds.
It is being asked to produce more protein.
As the world’s population grows and consumers increasingly seek affordable animal protein, poultry production continues to expand. Industry projections estimate the sector will grow at a CAGR of approximately 5–7% over the coming years.

But growth alone is not enough.
Producers are expected to deliver more meat with fewer resources, lower feed costs, and a smaller environmental footprint.
This means that every gram of feed matters more than ever before.
And that brings us back to the gut.
Because the difference between feed consumed and protein produced is ultimately determined by the efficiency of the digestive system.

The Future Begins in the Gut
For decades, poultry production focused on genetics, nutrition, and disease control.
The next frontier may be intestinal resilience.
Future improvements in productivity will likely come from better management of inflammation, enhanced barrier integrity, optimized microbiomes, and improved nutrient efficiency within the gastrointestinal tract.
The question may no longer be:

“How much feed did the bird consume?”

Instead, the more important question may be:
“How much of that feed actually became growth?”
The answer lies within the gut.
Not because it is merely another organ, but because it is the organ that determines how effectively all the others perform.
In an era of narrow margins, rising feed costs, heat stress, and antibiotic-free production, the healthiest gut may ultimately become the most valuable asset in the poultry house.

Introduction
Inclusion Body Hepatitis (IBH) is an economically important viral disease of broiler chickens characterized by sudden mortality, hepatitis, and the presence of intranuclear inclusion bodies in liver cells. The disease is primarily caused by Fowl Adenoviruses (FAdVs), particularly serotypes belonging to species D and E. IBH has become increasingly significant worldwide due to its impact on broiler performance, increased mortality, poor feed conversion, and substantial economic losses. The disease mainly affects young broiler chickens between 3 and 7 weeks of age, although birds of other ages may also be affected. Vertical transmission from breeder flocks and horizontal spread through contaminated litter, water, equipment, and personnel play major roles in disease dissemination.

Etiology
IBH is caused by Fowl Adenoviruses (FAdVs), non-enveloped double-stranded DNA viruses belonging to the genus Aviadenovirus within the family Adenoviridae. Several serotypes have been associated with disease outbreaks, including FAdV-2, FAdV-8a, FAdV-8b, and FAdV-11.
Predisposing factors include:
– Immunosuppression caused by Infectious Bursal Disease (IBD)
– Chicken Infectious Anemia (CIA)
– Mycotoxicosis (Poor quality of feed ingredients contaminated with fungus and Mycotoxins).
– Poor Biosecurity and Management
– High stocking density

Clinical Signs
Affected broiler flocks may exhibit:
– Sudden increase in mortality
– Depression and lethargy
– Huddling with Ruffled feathers
– Reduced feed and water consumption
– Usually affects birds of 3 to 5 weeks age, but can be seen in the chicks aging from 4-5 day old.
– Pale comb and wattles
– Poor weight gain
– Diarrhoea with mucoid droppings or green droppings
– Anemia in severe cases
Mortality rates generally range from 5–15%, but outbreaks may occasionally result in mortality exceeding 30%.

Post-Mortem Lesions
The most characteristic lesions are observed in the liver.
Gross Lesions
Liver
– Enlarged, swollen, and pale liver
– Yellowish discoloration
– Multifocal necrotic foci
– Petechial and ecchymotic hemorrhages
– Friable consistency
Kidneys
– Enlarged and pale kidneys
– Congestion
Heart
– Hydropericardium may occasionally be present
– Pale myocardium
Spleen
– Enlargement and congestion
Histopathological Lesions
Microscopic examination reveals:
– Severe hepatic necrosis
– Basophilic intranuclear inclusion bodies in hepatocytes
– Degeneration and destruction of liver cells
– Mononuclear cell infiltration
The presence of characteristic intranuclear inclusion bodies is considered pathognomonic for IBH.

Serology
Serological testing is useful for monitoring flock exposure and breeder immunity.
Common serological methods include:
ELISA (Enzyme-Linked Immunosorbent Assay)
– Detects antibodies against Fowl Adenovirus
– Useful for flock monitoring
– Evaluates maternal antibody levels
Virus Neutralization Test (VNT)
– Determines serotype-specific antibodies
– Primarily used in research and epidemiological investigations
Interpretation
– High antibody titers in breeders provide maternal protection to progeny.
– Seroconversion in broilers indicates field exposure.
– Paired serum samples can help determine recent infection.
Diagnosis
Diagnosis should be based on a combination of clinical history, post-mortem findings, histopathology, and laboratory confirmation.
Field Diagnosis
Suspect IBH when:
– Sudden mortality occurs in 3–7 week-old broilers.
– Enlarged, pale, hemorrhagic liver is observed.
– There is a history of immunosuppressive diseases.
Laboratory Diagnosis
Histopathology
– Demonstration of intranuclear inclusion bodies in hepatocytes.
Polymerase Chain Reaction (PCR)
– Highly sensitive and specific.
– Detects and identifies FAdV serotypes.
Virus Isolation
– Performed in chicken embryo liver cells or embryonated eggs.
Immunohistochemistry
– Detects adenoviral antigen within tissues.
Sequencing
– Used for epidemiological studies and strain characterization.

Treatment
There is no specific antiviral treatment for Inclusion Body Hepatitis.

Management is mainly supportive:
Supportive Therapy
– Multivitamin supplementation
– Vitamin E and Selenium administration
– Use D’Bio-Mix 20-25 mL per 100 birds and ABES-URZZA 20 ml for 100 birds.
– Ionic electrolyte (ABESTRAL) supplementation and probiotic prebiotic supplementation
— Adequate hydration
Control of Secondary Infections
– Antibiotics may be administered under veterinary supervision to control secondary bacterial infections.
Management Measures
– Reduce stress factors
– Improve ventilation
– Maintain litter quality
– Ensure proper nutrition

Prevention and Control
Effective prevention relies on biosecurity and breeder vaccination.

Biosecurity Measures
– All-in/all-out management
– Thorough cleaning and disinfection
– Restriction of farm visitors
– Proper disposal of dead birds
– Control of rodents and insects
– Sanitation of equipment and vehicles
Breeder Flock Management
– Monitor antibody levels regularly.
– Vaccinate breeders to ensure maternal antibody transfer.
– Prevent immunosuppressive diseases such as IBD and CIA.
Control of Vertical Transmission
– Maintain healthy breeder flocks.
– Conduct routine serological surveillance.
– Implement strict hatchery hygiene.

Vaccination Schedule
Vaccination strategies vary according to local epidemiology and circulating serotypes.
Breeder Vaccination Program
Age Vaccine
8–10 weeks Killed IBH (primary dose)
14–16 weeks Booster dose
18–20 weeks (before lay) Optional booster in high-risk areas
Broiler Vaccination
Routine vaccination of broilers is generally not practiced in many regions because protection is primarily achieved through maternal antibodies. However, live or inactivated vaccines may be considered in endemic areas under veterinary guidance.
Objectives of Vaccination
– Prevent vertical transmission
– Enhance maternal antibody levels
– Reduce mortality and production losses
– Improve flock uniformity

Economic Impact
IBH can result in:
– Increased mortality
– Poor growth performance
– Reduced feed efficiency
– Higher medication costs
– Increased carcass condemnation
– Significant financial losses to poultry producers

Conclusion
Inclusion Body Hepatitis remains an important viral disease of modern broiler production. Early diagnosis, strict biosecurity, breeder vaccination, and effective management practices are essential for disease prevention and control. Maintaining strong maternal immunity through breeder vaccination and minimizing immunosuppressive conditions can significantly reduce the impact of IBH on commercial poultry operations.