#PoultryPerformance – Vprint Infotech https://www.vprintinfotech.com Magazine Sat, 06 Dec 2025 10:55:27 +0000 en-US hourly 1 https://wordpress.org/?v=7.0.2 https://www.vprintinfotech.com/wp-content/uploads/2023/08/logo-feb-150x150.jpg #PoultryPerformance – Vprint Infotech https://www.vprintinfotech.com 32 32 Balancing Air Quality in Poultry Houses: Tackling Ammonia and Humidity for Health and Productivity https://www.vprintinfotech.com/balancing-air-quality-in-poultry-houses-tackling-ammonia-and-humidity-for-health-and-productivity/ Sun, 09 Nov 2025 06:22:50 +0000 https://www.vprintinfotech.com/?p=7326

Balancing Air Quality in Poultry Houses: Tackling Ammonia and Humidity for Health and Productivity

Dr. Pawar Rutik Namdev1 (MVSc Scholar), Dr. Shipra Tiwari1 (MVSc Scholar),
Dr. Mahendra Kumar Patel1 (Ph.D Scholar)
1College of Veterinary Science and Animal Husbandry, DUVASU Mathura (281001), India

 

Abstract
The environment within poultry houses plays a decisive role in the overall health, performance, and welfare of birds. Among various factors, the concentration of ammonia (NH₃) and the level of relative humidity (RH) are the most critical. Ammonia, released from the microbial breakdown of waste, and excessive humidity, which influences litter moisture, often work together to create poor air quality. This review highlights how these two factors are produced, their combined impact on broilers and layers, and outlines practical approaches for monitoring and management to maintain profitability and bird well-being.

1. Introduction
For poultry farmers, achieving optimal productivity requires not just good feed and genetics, but also maintaining a favorable environment inside the house. Air quality, ventilation, and litter condition all directly affect flock health. Ammonia gas and humidity levels are particularly important, as they can significantly influence bird growth, egg production, immune strength, and overall welfare. Excessive ammonia harms the respiratory tract, reduces feed intake, and lowers growth efficiency, while uncontrolled humidity leads to wet litter, higher ammonia emissions, and disease outbreaks. To ensure healthy flocks, ammonia should ideally be kept below 20–25 ppm and RH within 50–70%.

2. How Ammonia and Humidity Build Up
2.1 Generation of Ammonia
Ammonia is created naturally when uric acid in droppings is decomposed by bacteria. The process is intensified under warm, moist, and alkaline conditions. The type of litter material, stocking density, feed composition (especially protein levels), and frequency of manure removal all influence ammonia levels. Houses with poor cleaning routines or high moisture accumulation often experience higher NH₃ concentrations.

2.2 Role of Humidity
Humidity directly controls litter moisture content. High RH slows the evaporation of water from bedding, resulting in wet litter that promotes microbial activity and ammonia release. Conversely, very low RH increases dust particles in the air, which irritates the birds’ airways. Thus, moisture management is closely tied to controlling ammonia levels.

3. Impacts on Bird Health and Physiology
3.1 Respiratory Effects
Ammonia acts as a strong irritant to the respiratory tract. Continuous exposure damages the trachea and air sacs, reducing the ability of cilia to filter pathogens. Birds exposed to more than 20–25 ppm are more prone to respiratory diseases such as Newcastle, bronchitis, and Mycoplasma infections. Vaccination responses also tend to decline.

3.2 Eye and Skin Irritation
Chronic exposure to ammonia causes conjunctivitis, watery eyes, and corneal damage. High RH contributes to wet litter that leads to footpad dermatitis, hock burns, and breast blisters—all of which compromise welfare and reduce carcass quality at processing.

3.3 Growth and Feed Efficiency
High levels of ammonia reduce appetite, slow weight gain, and impair feed conversion. Even a small increase in feed conversion ratio (FCR) significantly raises production costs, especially in large flocks. Performance losses become severe when ammonia concentrations exceed 50 ppm for prolonged periods.

3.4 Immunity
Birds raised in poor air quality often show weaker immune responses. Prolonged exposure to ammonia not only stresses birds but also reduces antibody production after vaccination, leaving them vulnerable to disease outbreaks.

3.5 Egg Production
In layer flocks, poor litter conditions and elevated ammonia cause stress, leading to reduced laying rates, smaller egg size, and poor shell quality. Mortality may also rise due to an increased risk of secondary infections.

4. The Combined Impact of Ammonia and Humidity
Although ammonia and humidity can each harm poultry, their combination is especially damaging. High RH makes litter wetter, which in turn boosts ammonia emissions. Humid air also traps ammonia at bird level, ensuring birds inhale more of it. Together, these conditions encourage respiratory infections, coccidiosis outbreaks, poor weight gain, higher mortality, and overall production losses.

5. Monitoring Levels
5.1 Threshold Values
Ammonia: Should remain below 20–25 ppm (ideally closer to 10 ppm). Birds show signs of irritation even at levels humans may not detect by smell.

Relative Humidity: Best maintained between 50–70%. RH above 75% promotes wet litter, while RH below 40% leads to dust and dehydration.

5.2 Measurement Tools
Ammonia: Can be monitored using portable gas detectors, color tubes, or continuous electronic sensors.
Humidity: Inexpensive hygrometers placed at bird height provide reliable readings and are often integrated into automatic ventilation systems.

6. Strategies for Control
6.1 Ventilation
Proper ventilation ensures air exchange, dilutes gases, and removes excess moisture.

In cold weather: minimum ventilation prevents humidity build-up without chilling the birds. fans and circulation systems increase air movement and reduce heat stress.

6.2 Litter Management
Maintaining dry litter is essential. Turning litter, replacing wet spots, using absorbent bedding materials, and preventing drinker leaks are key practices. Chemical litter amendments such as alum or sodium bisulfate can reduce pH, minimizing ammonia release.

6.3 Nutrition
Adjusting feed formulations to match amino acid requirements reduces nitrogen excretion. Enzyme supplements and probiotics may also improve digestion and reduce ammonia in manure.

6.4 Housing Design
Well-insulated poultry houses with good drainage and properly installed nipple drinkers minimize litter moisture. Preventing condensation on walls and ceilings also helps keep humidity under control.

6.5 Advanced Methods
Technologies like air scrubbers, biofilters, or controlled ozone applications are being tested for large commercial units. Automated environmental control systems that integrate NH₃ and RH sensors with fans and heaters are becoming increasingly popular.

7. Economic Importance
Poor air quality silently eats into farm profits. Lower feed efficiency, reduced weight gain, carcass downgrades, increased mortality, and higher veterinary costs all add up to significant economic losses. Studies show that ammonia-related performance drops can cost large poultry complexes thousands of dollars weekly. Investing in better litter management, ventilation, and nutritional adjustments often proves cost-effective in the long run.

8. Evidence and Case Studies
Field surveys often reveal ammonia exceeding safe levels during winter when ventilation is minimized, leading to higher respiratory issues and welfare concerns. Controlled trials consistently show that birds exposed to even moderate ammonia (20–30 ppm) suffer from lower growth rates, poorer immune response, and more lesions compared to those raised under optimal conditions. Interventions such as litter acidifiers, improved diet formulations, and enhanced ventilation schedules have been shown to significantly reduce ammonia emissions and improve performance.

9. Recommendations for Farmers
– Check RH daily: maintain between 50–70%.
– Monitor ammonia regularly: aim for <20 ppm.
– Fix water leaks immediately to avoid wet litter.
– Adjust ventilation by season to balance temperature, RH, and air quality.
– Work with a nutritionist to optimize protein levels in diets.
– Use litter amendments wisely to reduce ammonia emissions.

10. Future Outlook
The integration of smart sensors and artificial intelligence into poultry housing systems may soon allow farmers to predict ammonia build-up and adjust ventilation automatically. Further research is needed to quantify the long-term welfare and production benefits of advanced technologies and to make them affordable for small- and medium-scale farmers.

11. Conclusion
Ammonia and humidity are closely linked environmental challenges in poultry houses. Both negatively affect bird health, welfare, and productivity when not controlled. Together, they magnify each other’s harmful effects, resulting in economic losses and compromised flock performance. Regular monitoring, proactive litter and ventilation management, balanced nutrition, and modern environmental control tools are essential for maintaining a healthy environment. Addressing these issues not only supports profitability but also improves animal welfare, ensuring sustainable poultry production.

 

 

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Water Treatment & Biosecurity – The Twin Pillars of Poultry Management https://www.vprintinfotech.com/water-treatment-biosecurity-the-twin-pillars-of-poultry-management/ Sun, 09 Nov 2025 04:38:51 +0000 https://www.vprintinfotech.com/?p=7319

In today’s poultry industry, two factors play a decisive role in ensuring profitable, sustainable, and disease-free production:

Water Treatment and Biosecurity.
Together, they safeguard flock health, enhance performance, and reduce dependence on antibiotics.

1. Water Treatment in Poultry
Water is often called the “forgotten nutrient,” yet it is the most critical element in poultry production. Birds consume twice as much water as feed, and any compromise in water quality directly impacts growth, egg production, and immunity.

Key Challenges in Water Quality
– Microbial contamination: Bacteria such as E. coli and Salmonella spread through untreated water.
– Biofilm formation: Organic residues in pipelines harbor pathogens.
– Chemical impurities: High TDS, hardness, iron, or nitrates affect digestion and performance.
– pH imbalance: Acidic or alkaline water reduces feed intake. Water Treatment Practices
– Filtration to remove physical impurities.
– Acidification to maintain pH (5.5–6.5) and inhibit bacterial growth.
– Chlorination / Hydrogen Peroxide / Ozone for disinfection.
– Regular waterline flushing to prevent biofilm buildup.
– Monitoring TDS, hardness, and microbial load routinely.

2. Biosecurity in Poultry
Biosecurity means preventing disease entry and spread on the farm. With rising concerns about Antimicrobial Resistance (AMR) and the push toward antibiotic-free production, biosecurity has become more important than ever.

Three Levels of Biosecurity
1. Conceptual Biosecurity – Farm location, distance from other poultry units, controlled entry points.
2. Structural Biosecurity – Physical barriers, fencing, bird-proof sheds, water sanitation system.
3. Operational Biosecurity – Day-to-day practices like disinfection, vaccination, and visitor control.

Practical Biosecurity Measures
– Restrict farm access (only authorized persons allowed).
– Provide footbaths, hand sanitizers, and farm clothing.
– Disinfect vehicles, crates, and equipment before entry.
– Implement rodent and wild bird control programs.
– Maintain strict mortality disposal methods (incineration/composting).
– Regular vaccination and health monitoring.
– Keep detailed farm records for traceability.

3. Water Treatment + Biosecurity = Sustainable Poultry
While water treatment ensures internal health and performance, biosecurity provides external protection from infections. Both are complementary and essential.
– Clean water reduces gut-related diseases like colibacillosis and diarrhoea.
– Biosecurity reduces the risk of respiratory and viral infections.
– Together, they help in antibiotic-free poultry production, improve FCR (Feed Conversion Ratio), enhance bird welfare, and boost farmer profitability.

Water Quality Monitoring & Water-Borne Diseases in Poultry


Diagram shows that, the source of water we need to check, Ph, TDS, COLOUR, BACTERIA & VIRAL LOAD. This water will go to overhead tank & from there it will distribute to different Poultry shed tanks & through pipe & nipple it will available for birds, here we need to monitor the quality of water.

Importance of Water Sanitation in Poultry Production
In modern poultry production, the use of feed additives such as water and feed acidifiers, toxin binders, probiotics, and antibiotic growth promoters (AGPs) is a common recommendation by poultry nutritionists. Farmers are also increasingly incorporating low-cost protein sources like Rice DDGS, Maize DDGS, and Meat Meal (sometimes adulterated with leather powder) to reduce feed costs.

However, ignoring water sanitation remains one of the most critical mistakes in poultry farming. Even with balanced feed formulation and additives, if the water provided to the birds is contaminated, it results in:
• Loose droppings due to microbial contamination.
• Poor nutrient absorption – birds fail to utilize protein, energy, minerals, and vitamins in the diet.
• Increased incidence of diseases such as E. coli infections and Salpingitis.
• Weakened immunity and consequently poor production performance.

In contrast, a farm with proper water sanitation shows remarkable differences. For example, in one of my ideally managed farms, the birds consistently showed dry droppings (“DRY BEAT”), a clear indicator of good gut health and proper nutrient absorption. This success was achieved through:
• Regular water sanitation practices (disinfection, acidification, and monitoring).
• Ensuring feed hygiene along with the use of safe, food-grade raw materials.
• Strict biosecurity and management protocols.

Safe Water Treatment – A Farmer’s Responsibility

Many farmers currently use different chemicals such as chlorine gas, bleaching powder, and sodium hypochlorite for water treatment. They are not safe for poultry or humans. These compounds often leave harmful residues, alter water taste, reduce consumption, and may even add toxic by-products into the water. According to WHO guidelines, only food and pharmaceutical grade salt should be used for drinking water treatment — both for humans and poultry. The safest and globally recommended option is NaDCC (Sodium Dichloroisocyanurate), which ensures:
• Broad spectrum disinfection with very effective bacterial control
• Safe for poultry & human consumption
• No significant change in taste or odour
• Eco-friendly & easy handling
• Stable and longer shelf life compared to other chlorine sources

Using sub-standard chemicals not only compromises poultry performance (loose droppings, poor nutrient absorption, higher
disease load, chlorine toxicity) but also risks human food safety through residues in meat and eggs.
Key Impact: Farmers must understand that safe water treatment is not about the cheapest chemical, but about using WHO- recommended, food & pharma grade NaDCC for long-term health, productivity, and profitability.

Note: Why NaDCC (Food & Pharma Grade) is Always Better.

Among all the available chlorine-base compounds for water sanitation, Food & Pharma grade Sodium Dichloroisocyanurate (NaDCC) is the safest and most effective choice.

• WHO Recommended – Approved for safe drinking water treatment globally.
• Broad Spectrum Effectiveness – Provides strong and stable disinfection (48 hours’ stability).
• Safe for Birds & Humans – No harmful residues, no significant change in taste or odor.
• Eco-Friendly – No toxic by-products or sludge formation.
• Long Shelf Life – Up to 3 years, with easy effervescent tablet formulation.
• Ease of Use – Simple handling, no heavy cylinders or high manpower required.
• Therefore, NaDCC (Food & Pharma Grade) is always better than chlorine gas, bleaching powder, sodium hypochlorite, or halozone for ensuring Zero-Bacteria Water in poultry Farms.

Conclusion
In poultry management, prevention is always better than cure. Poultry farming success is not just about what we feed the birds, but also about the quality of water they drink every single day. Feed can be fortified, sheds can be modernized, but without clean water and strict sanitation, the full genetic potential of the flock can never be realized. Water is the simplest yet most powerful tool to secure healthy birds, higher productivity, and long-term profitability. Water treatment and biosecurity are not costs but investments that return multiple benefits in productivity, profitability, and sustainability.

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Impact of Ammonia and Humidity on Poultry https://www.vprintinfotech.com/impact-of-ammonia-and-humidity-on-poultry/ Mon, 11 Aug 2025 07:13:05 +0000 https://www.vprintinfotech.com/?p=7202 Introduction
In the world of poultry farming, two significant concerning factors are litter ammonia and relative humidity. The presence of ammonia gas released by uric acid decomposition in bird droppings is referred to as the litter ammonia level. High quantities of litter ammonia may negatively impact the respiratory system, eyes, and feet, resulting in decreased production and increased mortality rates. Relative humidity, on the other hand, refers to the amount of moisture in the air. Maintaining adequate humidity levels is critical for preventing pathogen growth and infection.

Poultry excreta comprises undigested feed protein and uric acid, which microbial enzymes convert to ammonia (NH3). Several litter characteristics, including pH, temperature, oxygen, moisture concentrations, and substrate availability, influence this conversion. The recommended limit for ammonia in a chicken shed is less than 10 ppm, however, up to 25 ppm is not detrimental. Ideally, the relative humidity should range between 50 and 70%. The rainy season, defective foggers, insufficient ventilation, water leaks, and other factors all contribute to increased humidity inside the shed.

Ammonia levels and humidity in poultry houses are interconnected. High relative humidity can exacerbate the adverse effects of high blood ammonia levels in poultry. In humid environments, more NH3 may be dissolved in the air droplets and inhaled into the blood during respiration by birds, consequently increasing the blood ammonia content. When ammonia gas is exposed to moisture, it reacts and forms a corrosive solution called ammonium which causes harm to birds. Additionally, high humidity can hinder the evaporation of moisture from the litter, causing it to retain more ammonia.

Deleterious Effects on Poultry:
1. Respiratory Issues: High levels of ammonia in the poultry house air can cause respiratory problems for the birds. Ammonia gas affects the trachea’s mucosal surface, causing paralysis of cilia, sometimes deciliation of epithelial cells, and causes necrosis of the mucosal epithelium.
2. Foot Lesions: The constant exposure of poultry to ammonia can cause severe foot lesions by causing chemical burns on the foot pads of birds, leading to painful and debilitating footpad dermatitis.
3. Eye Lesions: High concentrations of atmospheric ammonia for a prolonged duration causes irritation, conjunctivitis, and damage to the cornea of the eyes. Swelling and reddening of the eyelids, irritation, reddening of the conjunctiva and nictitating membrane, and partial or complete closure of the eyes are common clinical signs.
4. Reduced performance.

How to prevent it:
Along with farming management like dietary management, stocking density, proper ventilation, house temperature, litter management, etc., other supplements like Phytogenic Feed Additives can be supplemented in a poultry diet. A phytogenic feed additive increases the digestibility of nutrients within the gastrointestinal tract and reduces the gut inflammation caused by stressors.

Thereby may considerably increase the gut integrity of the birds. Phytogenic feed additives also alter gut microflora, minimizing the adverse effect of harmful bacteria on the gut. Less undigested and unabsorbed nutrients will be excreted through faeces from a healthy gut, which means less nitrogen excretion.

STODI, a Standardized Botanical Powder, is crafted with scientifically selected herbs improving the efficiency of feed utilization and overall performance of the birds. In various studies, it has been found that STODI supplementation has significantly reduced litter nitrogen (g/100g of litter) as compared to group without supplementation. STODI maintains the gut integrity and peristaltic movement of the gut which increases time for the protein and other nutrient utilization by the birds. This increased protein utilization leads to reduced excretion reduced excretion of nitrogen which in turn decreases the production of ammonia level in litter. Along with this STODI has shown to improve the gut microbiota level and gut immunity of the birds.

In conclusion, the combined impact of ammonia and humidity in the world of poultry farming underscores the critical importance of maintaining a balanced and controlled environment for the well-being and productivity of the birds. High levels of ammonia in poultry houses can lead to a range of deleterious effects. STODI, a polyherbal formulation has shown to reduce the ammonia level in litter with improved nutrient utilization and gut microbiota balance.

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Mycotoxins in the food chain: Understanding risks and exploring mitigation strategies https://www.vprintinfotech.com/mycotoxins-in-the-food-chain-understanding-risks-and-exploring-mitigation-strategies/ Fri, 06 Jun 2025 12:46:12 +0000 https://www.vprintinfotech.com/?p=7085

Mycotoxins in the food chain: Understanding risks and exploring mitigation strategies


By: Dr. Maloshrie Bora, Program Manager – Feed Safety, Trouw Nutrition South Asia

 

The safety of animal feed is increasingly compromised by a confluence of global challenges, notably mycotoxin contamination. These toxic metabolites, produced by molds such as Aspergillus and Fusarium, pose significant health risks to livestock and, by extension, to humans consuming animal products. Contributing factors include a shortage of quality raw materials, exacerbated by supply chain bottlenecks and geopolitical disruptions. Climate change further intensifies the issue by altering temperature and precipitation patterns, creating favorable conditions for mold growth and mycotoxin production. Additionally, inadequate storage and transportation facilities, often lacking proper ventilation and climate control, facilitate the proliferation of these harmful fungi. Together, these elements underscore the urgent need for comprehensive strategies to mitigate mycotoxin risks and ensure feed safety.

Even the smallest lapse in post-harvest handling can swiftly trigger the formation of harmful secondary metabolites like mycotoxins. Factors such as delayed drying, inadequate moisture control, and poor storage conditions can create an environment conducive to fungal growth, leading to rapid mycotoxin accumulation. For instance, aflatoxin contamination in maize has been linked to improper drying and storage practices, highlighting the critical importance of stringent post-harvest management to ensure food safety.

Mycotoxin contamination poses a significant threat to various stakeholders in the agricultural and food sectors, including farmers, feed producers, food processors, public authorities, and end consumers. These toxic compounds adversely affect animal health by impairing the gastrointestinal tract, suppressing the immune system, and disrupting nutrient absorption, leading to decreased productivity and increased susceptibility to diseases. Implementing a comprehensive 360-degree mitigation strategy—encompassing prevention, detection, regulation, and education—can effectively address this multifaceted issue and safeguard public health and economic interests.

The “Big 6” mycotoxins—aflatoxins, ochratoxins, fumonisins, zearalenone, deoxynivalenol (DON), and T2 toxin—are among the most prevalent and toxic secondary metabolites produced by molds affecting agricultural commodities. These toxins impact various species differently; for instance, aflatoxins primarily affect liver function in mammals, while zearalenone exhibits estrogenic effects leading to reproductive issues in ruminants and pigs.

The incidence and severity of mycotoxin contamination are influenced by environmental factors such as temperature, humidity, and rainfall, which can create conducive conditions for mold growth and toxin production. Not all mycotoxins are equally toxic across species; for example, DON is highly toxic to swine, whereas poultry are less affected. Climate change exacerbates the problem by altering weather patterns, potentially increasing the prevalence and distribution of mycotoxins in crops.

Aflatoxins occur worldwide in feed and feed stuffs which results in severe economic loss to poultry and livestock industries. The extent of Aflatoxin contamination varies with geographic location, farming methods and the susceptibility of commodities to fungal invasion during pre-harvest, storage, and processing periods. Numerous studies showed negative effects of Aflatoxin in broiler chickens including a decrease in the efficiency of feed utilization and body weight gain, liver damage, poor immune response, and increased mortality. Aflatoxin is shown to induce pathological alterations in important organs such as the liver, kidneys, and lymphoid organs. Furthermore, the transmission of aflatoxin B1(AFB1) and its metabolites from feed to animal edible tissues and products, such as the liver and eggs, becomes particularly important as a potential hazard for human health. Given the global economic importance of Aflatoxin, many strategies have been tried to minimize their negative impact. A successful prevention strategy must be economical and capable of eliminating all traces of toxin without leaving harmful residues and should not impair the nutritional quality of the commodities. Extensive research has been carried out using adsorbent (binder) materials that adsorbs to Aflatoxin molecule by means of ion exchange and thereby preventing their absorption into blood circulation. Among various binding agents, clays and yeast cell wall materials are the most tested. Silicates are the main group of clays that are studied extensively in terms of Aflatoxin binding. These include tectosilicates (zeolites), 1:1 phyllosilicates (kaolinite), 2:1 phyllosilicates (smectites, vermiculites, chlorites, micas) and sepiolite. All silicates, however, are not the same in terms of their ability to bind Aflatoxin and among the above, smectites have shown greater binding efficacy against Aflatoxin. The ability of smectite clays to bind mycotoxins depends on pH in the gut, molecular arrangements, and its geographic region of origin. Smectite clays possess high Aflatoxin adsorption capacity due to its high surface area, ion exchange capacity, and ability to swell in the presence of water, and the efficacy has been proven in vivo in broiler chickens. The leading hypothesis on the bonding mechanism between adsorbed aflatoxins and smectites is the electron donor–acceptor (EDA) model. Other models such as selective chemisorption, H-bonding, and bonding through furan rings were proposed.

The supplementation of smectite clay in feed to aflatoxin challenged broilers considerably reduced the magnitude of toxic effects of aflatoxin and improved growth and immune response. Hence, smectite clay could be successively used in feed to ameliorate the toxic effects of aflatoxins in broiler chickens.

Aflatoxin B1 (AFB1), deoxynivalenol (DON) and ochratoxin A (OTA) are ones of the most common and dangerous mycotoxins. AFB1, produced mainly by Aspergillus, is one of the most poisonous toxins, which is classified as Group I carcinogen by the World Health Organization due to its hepatoxicity, immunotoxicity, mutagenicity, genotoxicity, and carcinogenicity on variety of animals. DON, produced by many Fusarium molds, contamination in feeds induces anorexia, emesis, and damage to intestinal barrier and immune function in animals through suppressing the synthesis of nucleic and proteins . OTA, a toxic metabolite from Aspergillus and Penicillium molds, possesses hepatoxic, nephrotoxic, neurotoxic, immunotoxic, and teratogenic effects on liver and kidney. Long-term epidemiological investigations have shown that most of the global feed is exposed to more than one mycotoxin, and mycotoxin contamination of food and animal feed is a worldwide problem. Meanwhile, when three mycotoxins co-existed in the poultry feeds, their interaction have been further associated with significant alterations in the productivity and profitability of animals. Therefore, development of remediation strategies to prevent or mitigate the mycotoxicosis is imperative.

Trouw Nutrition’s TOXO® range offers a suite of mycotoxin binders designed to mitigate the negative effects of mycotoxin contamination in animal feed. These products are formulated to support animal health and performance by reducing the bioavailability of harmful mycotoxins.
These products are part of Trouw Nutrition’s comprehensive approach to mycotoxin risk management, aiming to ensure feed safety and optimize animal health and performance.

TOXO®-MX: Precision for Aflatoxins
TOXO®-MX is a specialized binder formulated to combat aflatoxins, particularly Aflatoxin B1, which can adversely affect dairy cows and other livestock. By incorporating purified smectite clays, TOXO®-MX effectively reduces the bioavailability of aflatoxins in the gastrointestinal tract. This reduction leads to a significant decrease in the excretion of Aflatoxin M1 in milk, ensuring compliance with regulatory standards and safeguarding consumer health. Additionally, TOXO®-MX enhances feed efficiency, as evidenced by improved milk production per kilogram of dry matter ingested in dairy cows.

TOXO®-XL: Comprehensive Protection Against Fusarium Mycotoxins
TOXO®-XL is an advanced binder designed to address the challenges posed by Fusarium-related mycotoxins, such as trichothecenes and fumonisins. This product combines smectite clays with specifically selected glucose biopolymers and purified β-glucans, which work synergistically to reinforce intestinal barrier function and modulate the immune response. The result is a comprehensive solution that not only binds and eliminates mycotoxins but also mitigates performance impairments caused by their exposure.

TOXO®: Broad-Spectrum Mycotoxin Binder
TOXO® serves as a versatile, broad-spectrum mycotoxin binder suitable for various animal species. It utilizes smectite clays to effectively reduce the bioavailability of a wide range of mycotoxins, including aflatoxins, ochratoxins, and zearalenone. By preventing the absorption of these toxins, TOXO® helps maintain animal health and performance, making it an essential component of comprehensive mycotoxin risk management strategies.
Collectively, the TOXO® product range represents a holistic approach to mycotoxin risk management, integrating advanced scientific formulations to protect animal health and ensure the safety of the food chain.

 

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An Overview of Activated Guanidinoacetic Acid (GAA) in Poultry Nutrition: Optimizing Feed Cost, Performance and Profitability https://www.vprintinfotech.com/an-overview-of-activated-guanidinoacetic-acid-gaa-in-poultry-nutrition-optimizing-feed-cost-performance-and-profitability/ Wed, 06 Nov 2024 12:25:29 +0000 https://www.vprintinfotech.com/?p=6701

Poultry production is one of the most advanced agricultural industries, playing a key role in the global food supply. While the poultry industry works to meet the rising demand for high-quality protein, the availability and cost of feed ingredients remain significant challenges for the poultry sector. Poultry feed accounts for more than 70% of total production costs, making it the largest expense in poultry farming. Fluctuations in the prices of key ingredients like corn and soybean meal, driven by global markets and climate conditions, significantly impact feed costs. Moreover, dependency on corn and oil as major energy sources in poultry feed, along with competition for these commodities from biofuel and human food industries, further drives prices up the poultry feed cost.

Ways (Strategies) to Reduce Poultry Feed Cost
1. Feed cost optimization through least cost formulation by use of software and precision nutrition by use of synthetic amino acids i.e. Lysine, Methionine, Threonine, Valine, Tryptophan, Arginine, etc. is a common practice followed by industry since the last three decades.
2. Enhancing dietary energy utilization is important and constantly under investigation. Application of feed additives i.e. exogenous enzymes (Amylase, Xylanases, ß-glucanase, α-Galactosidase, β-Mannanase, Protease, Phytase, etc.), and fat emulsifier to improve digestion and improve the availability of nutrients for absorption from the gut. By using an enzyme in poultry feed, poultry producers can reduce feed costs.
3. Cellular Energy: A key strategy for enhancing cellular metabolic efficiency is the use of Guanidinoacetic acid (GAA). GAA (C3H7N3O2) is an amino acid derivative, formed de-novo from L-arginine and L-glycine. It is the only precursor for creatine which plays a significant role in energy metabolism. GAA plays a crucial role in supporting cellular metabolism by ensuring optimal ATP availability, the primary energy source for cellular functions.
GAA, Adenosine Triphosphate (ATP), and Cellular Energy
After feed digestion, nutrients such as glucose, amino acids, and fatty acids are absorbed into the bloodstream and delivered to cells, where they are used to produce Adenosine Triphosphate (ATP) through various metabolic pathways. ATP serves as the cell’s primary energy source, often referred to as the “energy currency” because its stored energy is readily released when the bond between its second and third phosphate groups is broken, generating about 8 kcal/mole upon conversion to adenosine diphosphate (ADP).

ATP is fundamental for energy-intensive processes like muscle growth, egg production, sperm motility, nutrient absorption, immune response, and heat stress resilience.

Birds need more ATP & ATP deficiency can occur in the body in various conditions 
  • Rapid & fast growth -Where important amounts of ATP are absorbed for protein synthesis
  • Excitement or stress – Not only for escape but also for macrophages to fight pathogens
  • Low oxygen supply – Leading to low ATP production
  • Disturbed energy metabolism -Impaired mitochondrial function (Oxidative stress)
  • Low feed consumption especially in extreme summer
By ensuring a continuous supply of ATP, poultry can achieve better growth rates, improved reproductive performance, enhanced feed conversion efficiency, and overall health.

Guanidinoacetic acid (GAA)
plays a key role in cellular energy metabolism because it is the single immediate precursor of creatine. Creatine converts to creatine phosphate which is a key energy reserve in the body, and it helps to avoid the depletion of cellular ATP through the immediate provision of high-energy phosphates to regenerate the ATP molecule from adenosine diphosphate.

Although birds synthesize GAA and creatine from glycine and arginine amino acids, the endogenous production is insufficient to meet the demands of high performance and growth of modern broilers & breeders. So, GAA supplementation via the diet is beneficial for poultry. GAA requires the body’s nutrients for methylation and transferase enzyme to convert into creatine, which can be compromised under several situations such as climatic and production stress, leading to poor creatine delivery and reduced performance. In contrast, activated GAA (GAA along with methyl donor and transferase enzymes) bypasses these processes (methylation and enzyme synthesis), converting more efficiently into creatine in the body, ensuring high creatine levels, energy-sparing activity, arginine-sparing activity, and performance.

 

(Synthesis and metabolism of Guanidinoacetic acid (Image taken Krueger et al., 2010 & modified)

 

 

(Breakdown of ATP and release Energy)

The formation of GAA from L-Arginine and Glycine is regulated by a negative feedback mechanism involving both serum creatine and ornithine concentrations on L-Arg: Gly amidino transferase enzyme activity. However, dietary GAA supplements would bypass this rate-regulating mechanism. Therefore, increasing the dietary supply of L-arginine and Glycine would not increase creatine synthesis or its concentrations in muscle tissue beyond such regulated levels. De Groote, Braun, and Dilger (2018) reported muscle and serum creatine levels to be higher with supplemental GAA, compared to L-Arginine.
GAA (mg/kg) & Creatine (mg/kg) in different Feed Ingredients
Creatine is available only in animal protein-based feed ingredients. Its availability from external sources is questionable because creatine is heat-labile, and the rendering process temperature affects its levels in feed. A plant-based (vegetable) diet and its ingredients do not contain GAA and creatine.
Table 1. Feed ingredients contain Guanidinoacetic acid (GAA), creatine, and creatinine. (Krueger, Damme, and Lemme 2010).
Creatine requirements of modern broilers (adapted & modified form Khajali, et.al (2020)
A 21-day-old broiler chicken (985 g on average) with an average daily weight gain of 75 g (Aviagen 2019) would require 169 mg creatine.
The calculation is based on the assumption that 50% of weight gain is muscle (Kallweit et al., 1988) and muscle tissue contains 4.5 g/kg creatine (Lemme et al., 2007). For a more exact calculation of the CREA requirement, its turnover needs to be considered, as suggested by Tossenberger et al., (2016). Heat instability is the main issue that limits the use of creatine as a feed supplement for poultry (Vranes et al., 2017) because poultry diets are most often subjected to feed processing (pelleting) which imposes heat exposure of 70°C or higher (Slominski 2011).
Supplementation of GAA in Poultry Feed 
GAA, a direct precursor of CREA, has recently attracted attention as a feed additive for poultry due to its high thermal stability (Vranes et al., 2017), which makes it relatively stable during pelleting or extruding.
  • GAA has been officially registered as an animal feed additive by the EFSA (European Food Safety Authority) (2009; 2022) & the US-FDA (U. S. Food and Drug Administration)
  • GAA supplements account for 40% less cost compared to creatine.
  • GAA exerts many non-creatine roles, including the stimulation of insulin secretion, neuromodulation, and vasodilation.
  • GAA has an arginine-sparing potential of up to 149% in broilers, thus arginine is more readily available for metabolic processes other than GAA production
Effect of GAA on Poultry Performance
– Reduce feed cost & lower production cost
– Improve feed conversion ratio (FCR)
– Increase body weight gain, breast meat yield & dressing percentage
– Reduce muscle degeneration problems
– Improve semen quality & fertility – male breeders
– Improve chick quality – female breeder
– Reduce heat stress mortality & ascites
How GAA Optimizes Poultry Performance: In-Depth Look

1. Reduce feed cost (lower production cost) & Improve feed conversion ratio (FCR)

o Guanidinoacetic acid (GAA) is key in creatine synthesis, enhancing energy storage and transfer within muscle cells. Creatine, stored as phosphocreatine, supports the quick regeneration of ATP, which powers energy-intensive processes like muscle contraction, growth, and protein synthesis. GAA supplementation in poultry diets optimizes energy recycling, resulting in improved energy utilization and performance.

o As GAA enhances the bird’s endogenous creatine production, improving energy efficiency. This cellular energy efficiency allows nutritionists to reduce feed costs by lowering metabolizable energy (ME) by 30-60 kcal/kg at an inclusion rate of GAA @ 600 g/ton without affecting growth performance while reducing energy-rich ingredients like maize & oil.
o Furthermore, GAA is effective in low-protein diets also, enabling reduced crude protein levels without compromising performance. Studies show that supplementing GAA at 600-1200 g/ton in low-CP diets maintains optimal growth and carcass quality while reducing protein-rich ingredients like soybean meal.
o GAA has an arginine-sparing effect that reduces dietary arginine requirements by 10-15%, freeing up arginine for other vital functions and lowering feed costs.
o Lastly, GAA supplementation significantly improves the feed conversion ratio (FCR), reducing feed intake per unit of weight gain. Research indicates that GAA can improve FCR by 4.5 to 8.8 points, leading to more efficient growth and lower overall feed costs.
2. Increase body weight, breast meat yield, and meat quality 
o GAA supplementation increases creatine availability, supporting enhanced muscle energy metabolism. This translates to improved muscle growth in fast-growing broilers. Better energy delivery to muscle cells means more efficient feed utilization, promoting higher meat yield. Research has shown that supplementing broiler diets with GAA @ 600-1200 g/ton feed, leads to noticeable performance improvements, including significant gains in breast muscle mass, a highly valuable part of the poultry carcass. This contributes to both higher carcass quality and profitability.
o Dietary supplementation of GAA @ 1200 g/ton feed contributed to improving meat quality via ameliorating muscle energy expenditure and delaying anaerobic glycolysis of broilers. GAA supplementation in broiler diets may be an effective tool for improving meat quality by reducing myopathy severity including woody breast, white striping, and woody-like tender in heavy broilers.
3. Role of Guanidinoacetic Acid (GAA) in Broiler Breeders
o Guanidinoacetic Acid (GAA) supplementation offers multiple benefits in broiler breeders, enhancing fertility, hatchability, and chick quality. Studies have shown that GAA supplementation improves egg production and consistency. It also increases breeder vitality, enabling efficient mating in males and enhancing reproductive performance in deep litter systems.
o In male breeders, GAA plays a crucial role in improving fertility by enhancing sperm quality and viability. It supports the functioning of Sertoli cells, crucial for spermatogenesis, and increases ATP availability, resulting in higher sperm motility and better penetration capabilities. Improved sperm quality leads to higher fertility rates, and GAA supplementation helps prevent age-related reproductive deficits.
o In female breeders, GAA supplementation boosts creatine content in hatching eggs, supporting embryo development during crucial stages like organogenesis and skeletal formation. This leads to better hatchability, chick vitality, and postnatal growth.
o Supplementation of broiler breeder diets with GAA @ 1000-1200 g/ton feed is a promising strategy for optimizing the productivity, fertility, and hatchability of breeder birds, ultimately contributing to improved chick performance and overall flock efficiency.
4. Effect of GAA on heat stress mitigation
o During acute heat stress, the cellular energy demand increases and during chronic heat stress, mitochondrial adenosine triphosphate (ATP) generation is reduced. In addition, heat stress induces higher utilization of muscle energy reserves in the form of glycogen. On this note, it could be perceived that enhancing the cellular creatine-phosphocreatine energy shuttle system might offer benefits for the broiler subjected to heat stress. Indeed, this system functions as a backup to the adenosine ADP-ATP cycle to store and mobilize energy when required on short notice. GAA feeding improved survival during heat stress, supported by lower panting frequency. Another primary physiological response during HS is the increased blood flow to the body surface or upper respiratory tract to dissipate internal body heat (Yahav et al., 1997). Therefore, the blood flow to some visceral organs is significantly reduced. In this respect, Arginine plays a pivotal role as it is the nitrogenous precursor for the endogenous synthesis of nitric oxide by nitric oxide synthase. Nitric oxide is a potent vasodilator that directly relaxes vascular smooth muscle and modulates or inhibits the production and release of vasoconstrictors such as serotonin. Higher Arginine bioavailability might thus be beneficial for heat-stressed birds, as it has been demonstrated in Pekin ducks (Zhu et al., 2014). Furthermore, conclusively, it was demonstrated that dietary-supplemented GAA is able to spare Arginine in broilers (Dilger et al., 2013; DeGroot et al., 2018). Consequently, more Arginine would be available for its protein and other nonprotein functions, such as a precursor for nitric oxide and polyamines. GAA supplementation improved feed conversion ratio and survival, with the largest benefits in the finisher period when birds were subjected to heat stress.
Conclusion
In conclusion, Guanidinoacetic Acid (GAA) supplementation in poultry diets offers a multiple benefit in poultry. GAA supplementation in poultry diets allow to reduce feed cost, improves feed conversion ratios, increases body weight gain, and boosts breast meat yield. It effectively supports muscle growth, mitigates muscle degeneration issues, and enhances meat quality by reducing the severity of myopathies. In broiler breeders, GAA improves reproductive performance by increasing sperm quality and fertility in males while boosting egg and chick quality in females. Additionally, GAA enhances resilience to heat stress, leading to improved survival rates and economic profitability under challenging conditions. This makes GAA a valuable tool for optimizing poultry productivity, profitability, and overall flock health.
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