Introduction

Why it matters in modern poultry production
– Rapid multiplication of Eimeria can produce substantial intestinal injury within a short period.
– Subclinical coccidiosis may reduce feed efficiency, growth and flock uniformity without dramatic clinical signs.
– High oocyst contamination of litter increases exposure and repeated infection pressure.
– Effective control requires attention to parasite biology, farm management and appropriate anticoccidial programmes.

Etiology
Seven major Eimeria species are recognized in chickens. E. acervulina and E. maxima are frequently encountered, while E. tenella is particularly pathogenic and associated with severe caecal disease and haemorrhage (Yaqub et al., 2023). Species differ in preferred intestinal sites, lesion patterns and pathogenicity.

Transmission
The principal route is faecal–oral transmission. Birds ingest sporulated oocysts from contaminated litter, feed, water, equipment or the environment. Moisture, oxygen and suitable temperature favour sporulation, allowing infective oocysts to accumulate and maintain the infection cycle (Pal et al., 2023).
Life Cycle of EIMERIA

Ingestion of sporulated oocysts → release of sporozoites → epithelial invasion → multiplication → gamete formation → oocyst formation → faecal shedding → environmental sporulation.

Clinical Signs
Severity depends on Eimeria species, infective dose, bird age, immunity and environmental management. Signs include reduced feed intake, depression, ruffled feathers, drooping wings, enteritis, diarrhoea or dysentery, poor growth and increased mortality in severe cases (Pal et al., 2023).
– Reduced body-weight gain and flock uniformity
– Poor feed conversion and production performance
– Diarrhoea or blood-stained droppings in severe infections
– Dehydration, weakness and depression
– Mortality when tissue damage and blood loss are extensive
Species-specific sites

Post-Mortem Lesions
Post-mortem examination helps identify likely Eimeria species and estimate the distribution and severity of intestinal damage. Lesion patterns should be interpreted with clinical findings, litter condition, performance data and, where appropriate, laboratory diagnosis (Pal et al., 2023; Yaqub et al., 2023).

Key lesion patterns

Prevention and Control
Effective control integrates anticoccidial programmes with litter management, hygiene, stocking-density control, ventilation and sound flock management. Continuous or inappropriate use of a single anticoccidial can contribute to reduced efficacy and resistance selection; rotation, shuttle programmes, combinations and vaccination are among approaches used for longer-term control (Usman et al., 2011; Chapman, 2017; Noack et al., 2019).

Anticoccidial programmes
– Rotation changes the active ingredient or mode of action between production cycles.
– Shuttle programmes use different anticoccidial strategies during different feed phases.
– Combination programmes can broaden anticoccidial activity and may help address reduced sensitivity when appropriately designed (Chapman & Rathinam, 2022).
– Vaccination can provide controlled exposure to selected Eimeria strains and support protective immunity.

Ionophore vs Chemical

Combination programmes
Combining compatible anticoccidial activities can broaden control and reduce dependence on a single mode of action. Programme selection should consider disease pressure, previous anticoccidial history, susceptibility patterns, compatibility and label requirements (Chapman & Rathinam, 2022).

STALLEN’S DUAL APPROACH TO COCCIDIOSIS CONTROL
Stallen South Asia offers a dual approach to coccidiosis management with Manacox Plus, bringing together ionophore and chemical anticoccidial activity in one formulation. This approach is designed to support practical, structured coccidiosis-control programmes while reducing dependence on a single mode of action.

MANACOX PLUS
Manacox Plus is a dual-active anticoccidial formulation combining an ionophore and a chemical anticoccidial. It contains Monensin Sodium 8% + Nicarbazin 8% for practical coccidiosis prevention programmes in broilers.
Key Product Points

WHY A DUAL APPROACH
Using monensin sodium together with nicarbazin brings ionophore and chemical anticoccidial activity into one formulation. This can fit structured prevention programmes where the objective is effective control without unnecessary reliance on a single mode of action. Use should follow the approved label and veterinary guidance.
Practical use
– Use within a planned farm coccidiosis-control programme.
– Maintain good litter quality, ventilation, stocking density and drinker management.
– Review anticoccidial history and flock response when planning future programmes.
– Follow approved dose, withdrawal period and compatibility instructions.

References are available on request.

Lode Nollet, Global Product Manager Poultry Enzymes, Huvepharma

Nutritional strategies to support the production of high quality, low cost and safe animal products are a must nowadays. The relationships between health, nutrition, welfare, and environment need to be considered. In poultry production, increasing feed costs are imposing pressure on the profitability of the farmer, so nutritionists seek to reduce feed costs whilst maintaining animal performance and gut health. Several strategies, with tangible tools to support this, are discussed in this article.

CONTROLLING COCCIDIOSIS

Coccidiosis, caused by protozoan parasites of the genus Eimeria, is one of the most widespread and difficult to manage poultry diseases, resulting in considerable economic losses in the broiler industry. Insufficient or inadequate control of coccidiosis will result in gut health damage and provide a pathway for other pathogens to proliferate.

For instance, suboptimal coccidiosis control combined with a high amount of undigested protein will create an ideal situation for the proliferation of Clostridia spp. Birds suffering from clinical coccidiosis will show typical signs like diarrhoea, bloody droppings, increased mortality, decreased feed intake and impaired performance.

Inadequate control of coccidiosis leads to impaired growth and feed conversion ratio, without the presence of evident clinical signs. This is subclinical coccidiosis.

Intensive methods of production of poultry favour the reproduction of Eimeria. Consequently, coccidiosis is a continuing problem requiring constant attention and, in the case of broilers, a need for continuous supplementation with anticoccidial drugs or coccidiosis vaccines, in addition to in-feed anticoccidials. Coccidiosis control combined with a good monitoring programme will be the base of any gut health management programme.

IMPROVING FEED DIGESTIBILITY

Improving digestibility of the feed can be achieved by selecting highly digestible feedstuffs. However, this will increase the feed price. The improvement of the digestibility of feed by using enzymes able to degrade Non-Starch Polysaccharides (the so-called NSPases) will not only lead to lowering the feed cost at formulation, but also exert a positive effect on the bird’s gut health.

The NSPases contain xylanase or xylanase-based enzymatic complexes, and their mode of action includes the hydrolysis of soluble arabinoxylans, which minimises intestinal viscosity, preventing the overgrowth of microflora and thereby reduces gut health disorders.

Together with the efficient reduction in viscosity, NSPases will also hydrolyse insoluble arabinoxylans. This action will unlock nutrients (mainly starch and proteins) which are trapped in the cell walls of the vegetable feed ingredients (the so called ‘cage effect’ of insoluble fibres).

Using the correct NSPase leads to improved digestibility of starch and protein. The latter is of particular importance as high levels of undigested protein in the (last) part of the intestine is a breeding ground for protein-loving pathogens like Clostridium spp, causing necrotic enteritis.

The breakdown of arabinoxylans by NSPase also yields arabino- oligosaccharides (AXOS) which are known to be fermented by the microflora in the lower part of the intestine to butyrate, which is a major energy source for villi regeneration allowing good gut health status.

Phytases have been shown not only to break down phytate to release phosphorus, but by doing so, to also destroy the anti-nutritional factor phytate.

This not only leads to a reduction of endogenous protein losses, but also liberates protein and amino acids which are complexed by phytate, enhancing their digestibility.

SUPPORTING THE MICROBIOTA

The relationship between a healthy gut and the animal’s microbiota is undeniable. As part of the holistic approach, the inclusion of probiotics in the nutritional programme offers a way of supporting gut health from a microbial perspective.

The mode of action of probiotics is usually multifactorial, including (but not limited to) the production of beneficial metabolites or the direct competition with unwanted bacteria. As a result, probiotics often help to balance the present microbiota and improve its robustness, supporting general gut health in the process. Probiotics can be incorporated into the feed or drinking water, depending on the strain and formulation used.

Although there are many commercial options available, the preferred product of choice should be based on a single unique strain, capable of forming spores and with a proven and researched mode of action. Such probiotics increase the ease of use, whilst ensuring product efficacy.

Good examples are B-Act®, containing viable spores of Bacillus licheniformis, based on Clostridium butyricum. Probiotics allow producers to support their animals’ gut health efficiently, setting them up for a successful production period from start to finish.

CONCLUSION

Gut health management is of paramount importance to the profitability of poultry farming. The strategy behind managing optimal gut health should contain a combination of the most important control tools on the market available today: an adequate and well thought-through coccidiosis control programme, combined with an NSP enzyme and a phytase, and topped off by a well-functioning probiotic.

To know more, please contact Huvepharma technical team

Huvepharma SEA (Pune) Pvt. Ltd.

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