However, despite its widespread use, SCC presents several practical challenges, including its highly hygroscopic nature, reduced feed stability, accelerated degradation of certain vitamins, and the formation of trimethylamine (TMA) during microbial metabolism. These limitations, coupled with the industry’s growing focus on efficiency, sustainability, and precision nutrition, have driven the search for more advanced nutritional solutions.

Why Liver Health Matters More Than Ever
In poultry, the liver is the primary site of lipogenesis, accounting for nearly 80–85% of total fatty acid synthesis. Every day, it coordinates the conversion of nutrients into energy, regulates lipid metabolism, synthesizes proteins, and supports numerous physiological functions essential for growth and production. When lipid metabolism becomes impaired, triglycerides accumulate within liver cells, leading to excessive fat deposition, poor feed utilization, reduced growth performance, and an increased risk of fatty liver conditions. These metabolic disturbances can significantly impact both biological efficiency and economic returns. Consequently, maintaining optimal liver function is no longer viewed merely as a health objective; it has become a key driver of productivity and profitability in modern poultry production.

Kolin Plus® : A New Generation Phytogenic Solution
Developed as a scientifically validated phytogenic alternative to synthetic choline chloride, Kolin Plus® represents a new approach to metabolic nutrition. Rather than functioning solely as a nutrient replacement, Kolin Plus® supports liver health and fat metabolism through multiple interconnected biological pathways. Formulated from carefully selected botanical ingredients rich in bioactive compounds, Kolin Plus® works by influencing key metabolic processes involved in lipid synthesis, fat mobilization, fatty acid oxidation, and energy utilization. This multi-pathway mode of action enables the bird to utilize nutrients more efficiently while supporting optimal hepatic function. Backed by transcriptomic research and performance validation studies, Kolin Plus® exemplifies the shift from conventional nutrient supplementation to scientifically driven metabolic optimization.

A Transcriptomic Window into Poultry Metabolism
One of the most exciting developments in animal nutrition has been the application of transcriptomics to understand how dietary interventions influence biological functions.
Transcriptomics enables researchers to evaluate thousands of genes simultaneously and identify the molecular pathways affected by nutritional interventions. To unravel the molecular basis of Kolin Plus® activity, liver gene expression profiling was conducted in broilers challenged with choline-deficient diets. The analysis identified key genes and signaling pathways involved in lipid synthesis, mobilization, oxidation, and overall hepatic lipid regulation. The gene expression patterns were studied for four groups normal diet: normal, choline chloride deficient, Kolin Plus®, and CCL using microarray on day 42. The hierarchical cluster analysis was carried out on 12,614 differentially expressed genes (DEGs) with a similar expression.

Regulating Fat Synthesis at Its Source
One of the most significant findings from transcriptomic research was the modulation of genes involved in hepatic fat synthesis. Key genes associated with lipogenesis—including PPARG, ACACA, ACLY, and LIPC were regulated in a manner that supports healthier lipid metabolism. These genes play important roles in: Fatty acid synthesis, Triglyceride accumulation, Lipid storage, Hepatic lipid regulation. By influencing these pathways, Kolin Plus® helps create a metabolic environment that favours efficient nutrient utilization while reducing excessive fat deposition within the liver. (Table 1, Fig1)

Figure 1. Effect of KP on gene expression related to de novo lipogenesis.
Activating the Fat-Burning Machinery
While reducing fat synthesis is important, optimal metabolic health also requires efficient utilization of stored fats. The transcriptomic analysis revealed enhanced expression of genes associated with fatty acid oxidation, including:  CPT1A, PPARGC1A, HADHB, PNPLA2
These genes are directly involved in transporting fatty acids into mitochondria and converting them into usable energy through β-oxidation. In practical terms, this means the bird becomes more efficient at utilizing dietary energy rather than storing it as excess fat.
Further studies demonstrated increased circulating levels of L-carnitine in supplemented birds.
L-carnitine serves as the transport system that carries long-chain fatty acids into mitochondria, where they are oxidized to generate energy. Improved L-carnitine status has been associated with:
– Enhanced fat utilization
– Reduced carcass fat deposition
– Improved energy efficiency
– Better production performance
This finding provides an important physiological link between molecular changes and measurable production outcomes. ((Table 1, Fig 2)

Fig 2: Effect of KP on catabolism of lipids (lipolysis and beta-oxidation of fatty acids.

From Molecular Science to Farm Performance
The true value of any nutritional intervention lies in its ability to improve on-farm performance.

Research Studies has demonstrated benefits including:
– Improved body weight gain
– Better feed conversion ratio (FCR)
– Reduced fat accretion
– Enhanced livability
– Improved European Production Index (EPI)
These improvements reflect the practical impact of optimizing lipid metabolism and liver function.  Rather than acting as a simple replacement for choline, this approach supports multiple interconnected pathways that collectively improve metabolic efficiency.

Sustainability Through Better Metabolism
Modern poultry production increasingly demands solutions that are not only effective but also sustainable. Improved lipid utilization means more dietary energy is directed toward productive purposes rather than being lost through inefficient metabolism.
This can contribute to:
– Better feed efficiency
– Lower resource utilization
– Reduced environmental impact
– Improved economic sustainability
As the industry continues to pursue precision nutrition and sustainable production systems, metabolic optimization will play an increasingly important role.

Conclusion
The future of poultry nutrition is moving beyond simple nutrient supplementation toward a deeper understanding of how nutrition influences biological systems. Advances in transcriptomics and nutrigenomics have shown that phytogenic technologies can regulate gene expression, optimize lipid metabolism, support mitochondrial function, and enhance metabolic efficiency.
By influencing key pathways involved in fat synthesis, lipid transport, and fatty acid oxidation, these next-generation nutritional solutions help improve liver health, nutrient utilization, and production performance. Kolin Plus®, backed by transcriptomic validation and performance studies, exemplifies this scientific approach by supporting metabolic health through multiple biological pathways rather than functioning as a conventional choline replacement alone.
As the poultry industry continues to focus on efficiency, profitability, and sustainability, scientifically validated phytogenic solutions such as Kolin Plus® are redefining metabolic management and shaping the future of precision poultry nutrition.

The meeting commenced with an introductory address by Mr. Deepak Khosla, General Manager (Marketing), who welcomed the participants and highlighted the company’s commitment to delivering science-based solutions for the poultry industry.

Dr. Prakash Reddy, DGM (Technical), delivered a currently relevant and focused presentation on “Hatchery Vaccines and Vaccination: Catching the Future”. He emphasized on the emergence of pathogens which are critical for designing effective control strategies because it reveals key vulnerabilities, transmission dynamics (vertical), and potential immune evasion mechanisms. Highlighted the emerging vaccine technologies opening new fields of possibilities for disease control and disease management, which include genotype based vaccines, vector vaccines, immune complex vaccine etc. The novel vaccine technologies would likely impose completely novel immune pressure or selection for resistance with enhanced immunosuppression and changes in patterns of antigenic variation, tissue tropism, and invasion pathways, so should be selective. Lastly, he updated the Innovative hatchery vaccination methods adapted in India for mass administration with speed and accuracy with ease of adaptation of semi-automated subcutaneous vaccination, spray vaccination etc. in day old chicks with a check on vaccinal reactions, errors and miss outs.

The second session, “Improving Broiler Performance through Effective Water Sanitation and Precise Medication Dosing,” was presented by Dr. Datta Kulkarni, DGM (Technical). He discussed how good water quality, effective sanitation, and accurate medication dosing can help enhance broiler health, performance, and farm profitability.

The programme concluded with valuable remarks from Mr. H. S. Padda, DGM, (Marketing), who underlined the importance of adopting scientific and practical approaches to address emerging poultry health challenges. Mr. Shashi Bhushan, AGM, (Marketing), delivered the vote of thanks and expressed gratitude to the speakers and participants for making the meeting informative and successful.

The technical meeting reaffirmed Ventri Biologicals’ commitment to advancing poultry health through knowledge sharing, innovation, and effective field-level solutions.

Lode Nollet, Global Product Manager Poultry Enzymes, Huvepharma

Nutritional strategies to support the production of high quality, low cost and safe animal products are a must nowadays. The relationships between health, nutrition, welfare, and environment need to be considered. In poultry production, increasing feed costs are imposing pressure on the profitability of the farmer, so nutritionists seek to reduce feed costs whilst maintaining animal performance and gut health. Several strategies, with tangible tools to support this, are discussed in this article.

CONTROLLING COCCIDIOSIS

Coccidiosis, caused by protozoan parasites of the genus Eimeria, is one of the most widespread and difficult to manage poultry diseases, resulting in considerable economic losses in the broiler industry. Insufficient or inadequate control of coccidiosis will result in gut health damage and provide a pathway for other pathogens to proliferate.

For instance, suboptimal coccidiosis control combined with a high amount of undigested protein will create an ideal situation for the proliferation of Clostridia spp. Birds suffering from clinical coccidiosis will show typical signs like diarrhoea, bloody droppings, increased mortality, decreased feed intake and impaired performance.

Inadequate control of coccidiosis leads to impaired growth and feed conversion ratio, without the presence of evident clinical signs. This is subclinical coccidiosis.

Intensive methods of production of poultry favour the reproduction of Eimeria. Consequently, coccidiosis is a continuing problem requiring constant attention and, in the case of broilers, a need for continuous supplementation with anticoccidial drugs or coccidiosis vaccines, in addition to in-feed anticoccidials. Coccidiosis control combined with a good monitoring programme will be the base of any gut health management programme.

IMPROVING FEED DIGESTIBILITY

Improving digestibility of the feed can be achieved by selecting highly digestible feedstuffs. However, this will increase the feed price. The improvement of the digestibility of feed by using enzymes able to degrade Non-Starch Polysaccharides (the so-called NSPases) will not only lead to lowering the feed cost at formulation, but also exert a positive effect on the bird’s gut health.

The NSPases contain xylanase or xylanase-based enzymatic complexes, and their mode of action includes the hydrolysis of soluble arabinoxylans, which minimises intestinal viscosity, preventing the overgrowth of microflora and thereby reduces gut health disorders.

Together with the efficient reduction in viscosity, NSPases will also hydrolyse insoluble arabinoxylans. This action will unlock nutrients (mainly starch and proteins) which are trapped in the cell walls of the vegetable feed ingredients (the so called ‘cage effect’ of insoluble fibres).

Using the correct NSPase leads to improved digestibility of starch and protein. The latter is of particular importance as high levels of undigested protein in the (last) part of the intestine is a breeding ground for protein-loving pathogens like Clostridium spp, causing necrotic enteritis.

The breakdown of arabinoxylans by NSPase also yields arabino- oligosaccharides (AXOS) which are known to be fermented by the microflora in the lower part of the intestine to butyrate, which is a major energy source for villi regeneration allowing good gut health status.

Phytases have been shown not only to break down phytate to release phosphorus, but by doing so, to also destroy the anti-nutritional factor phytate.

This not only leads to a reduction of endogenous protein losses, but also liberates protein and amino acids which are complexed by phytate, enhancing their digestibility.

SUPPORTING THE MICROBIOTA

The relationship between a healthy gut and the animal’s microbiota is undeniable. As part of the holistic approach, the inclusion of probiotics in the nutritional programme offers a way of supporting gut health from a microbial perspective.

The mode of action of probiotics is usually multifactorial, including (but not limited to) the production of beneficial metabolites or the direct competition with unwanted bacteria. As a result, probiotics often help to balance the present microbiota and improve its robustness, supporting general gut health in the process. Probiotics can be incorporated into the feed or drinking water, depending on the strain and formulation used.

Although there are many commercial options available, the preferred product of choice should be based on a single unique strain, capable of forming spores and with a proven and researched mode of action. Such probiotics increase the ease of use, whilst ensuring product efficacy.

Good examples are B-Act®, containing viable spores of Bacillus licheniformis, based on Clostridium butyricum. Probiotics allow producers to support their animals’ gut health efficiently, setting them up for a successful production period from start to finish.

CONCLUSION

Gut health management is of paramount importance to the profitability of poultry farming. The strategy behind managing optimal gut health should contain a combination of the most important control tools on the market available today: an adequate and well thought-through coccidiosis control programme, combined with an NSP enzyme and a phytase, and topped off by a well-functioning probiotic.

To know more, please contact Huvepharma technical team

Huvepharma SEA (Pune) Pvt. Ltd.

42, ‘ Haridwar’, Road 2 A/B, Kalyani Nagar, Pune 411006 Customer Care Contact: +91 20 2665 4193

Email: salesindia@huvepharma.com Website: www.huvepharma.com

By : Dr Maloshrie Bora, Program Manager (Trace Minerals), Trouw Nutrition South Asia

Trace minerals such as zinc, copper, and manganese are fundamental to poultry health, acting as cofactors in vital biochemical pathways: skeletal development, immune defenses, antioxidative systems, enzyme functions, feathering, and reproductive performance. Yet, the typical composition of feed ingredients often falls short of modern poultry standards. That’s why precision mineral nutrition—providing the right mineral at the right time and in the right form—is essential to support optimal broiler growth, eggshell integrity in layers, and fertility in breeders.

While inorganic sources like sulfates and oxides have been staples for decades, they suffer from low bioavailability and reactiveness. These soluble compounds can prematurely release minerals, which then form insoluble complexes with phytate or binding agents in the gut, diminishing absorption and even degrading vitamins or enzymes in the premix. This not only reduces feed efficiency but also increases mineral excretion, raising environmental concerns. Organic (chelate) minerals improved this situation, but often at a premium cost and with variable potency. Enter the next generation: hydroxy trace minerals. Hydroxy trace minerals, like copper, zinc, and manganese hydroxychloride, represent the latest leap in mineral nutrition. Their crystalline, covalent structure is non-hygroscopic and non-reactive in feed and the upper gut. This structure allows slow, controlled release of minerals at the ideal intestinal absorption site, significantly improving bioavailability. They resist premature dissolution, ensuring minerals are released more slowly and absorbed where it matters most.

Research across poultry sectors consistently shows that hydroxy trace minerals outperform inorganic sources. Broilers fed hydroxy copper and zinc achieved 7–8% heavier carcasses and a noticeable boost in breast meat yield. In independent trials, hydroxy-supplemented flocks maintained or improved feed conversion ratios while using lower inclusion levels than sulfate-based diets . Moreover, in antibiotic-free or necrotic enteritis challenge models, hydroxy minerals reduced pathogen load and mortality, performing on par with ionophores. Layers also benefit: eggshell quality improves, feed remains stable longer (less oxidation), and FCR gains are consistent when inorganic Cu, Zn, Mn are replaced with hydroxy versions. Breeder flocks, too, see enhanced fertility and hatchability under precision hydroxy mineral regimes.
Beyond performance, hydroxy trace minerals contribute to gut integrity and immune defense. Broilers on hydroxy mineral diets exhibited reduced cecal enterobacteria and maintained tight junction integrity, translating into healthier birds and better carcass quality.

Discover IntelliBond®: Precision You Can Trust
Among hydroxy trace mineral solutions, Trouw Nutrition’s IntelliBond® stands out as a premium, thoroughly validated choice. Designed to optimize delivery of copper, zinc, and manganese, IntelliBond features:

– High bioavailability and potency : thanks to stable, covalent crystalline bonds that release minerals at the optimal intestinal site.

– Enhanced feed stability and nutrient preservation : safeguarding enzymes like phytase and vitamins from degradation in premixes

– Improved bird performance and economics : with independent studies showing better feed conversion, heavier carcasses, superior egg output, and healthier flocks under stress.

– Environmental sustainability : with reduced inclusion rates and lower mineral excretion promoting cleaner production.

– Unmatched versatility across poultry species and life stages : including broilers, layers, and breeders—even under challenging conditions like heat stress or compromised hygiene. This adaptability has been validated across multiple trials and production environments.

Proven Performance Across Poultry Types
A Spanish study comparing hydroxy vs. sulfate-fed broilers at nutritional levels found that those receiving hydroxy minerals (IntelliBond C and Z) achieved 7.4% higher live weights, 7.7% heavier carcasses, and 16.1% breast meat yield, versus 15.3% in the sulfate group. Another Trouw Nutrition joint trial with the University of New England demonstrated improved bone integrity (tibia breaking strength) and breast meat zinc content in broilers fed 100 ppm IntelliBond Zn, with gut integrity maintained. In antibiotic-free commercial conditions, hydroxy copper-chloride combined with organic acids matched or exceeded the performance gains of feed antibiotics while improving egg weight, mass, and feed efficiency in layer hens. These findings highlight the ability of IntelliBonds to deliver consistent productivity gains across broilers, layers, and breeders—even under stress or antibiotic-free regimes. Trouw Nutrition India has been pioneering mineral-precision feeding. “Trouw Talks” events in Karnal and Hyderabad, unveiled IntelliBond’s OptiSize® technology—highlighting uniform, stable crystals that protect premix integrity and animal performance. Trouw Nutrition’s new premix plant near Hyderabad supports local production of trace minerals, vitamins, and specialized premixes—readying India for advanced feed solutions. This investment and local research infrastructure underline Trouw Nutrition’s strong commitment to validating hydroxy mineral efficacy under Indian production conditions.

Why IntelliBond® Stands Out
Developed over two decades and backed by 200+ global trials, IntelliBond® hydroxy trace minerals ensure predictable delivery and dependable results through:
– Superior bioavailability due to controlled release and crystalline stability

– Enhanced feed stability, maintaining vitamins, enzymes, and reducing oxidation in premixes

– Animal performance gains, improving carcass weight, egg production, feed conversion, and profitability

– Gut health, by reducing pathogenic bacteria and preserving gut barrier integrity in broilers
– Environmental responsibility, lowering mineral excretion while supporting sustainability-focused operations

Precision Manufacturing and Traceability
Trouw Nutrition’s OptiSize® technology guarantees uniform particle size and non-hygroscopic behavior. Its low reactivity protects feed integrity, while rigorous traceability—from raw material origins to lot distribution—ensures feed safety and compliance.

Modern poultry production demands precision: the right trace mineral, in the right form, at the right level. Hydroxy trace minerals—especially IntelliBond®—deliver on that promise. Scientific evidence and Trouw Nutrition’s local investments prove that these superior minerals enhance productivity, welfare, and sustainability in broilers, layers, and breeders. By choosing IntelliBond®, nutritionists and producers gain a trusted, research-backed solution that fosters better performance, protects investments, and advances poultry industry goals in India and beyond.