#AnimalNutrition – Vprint Infotech https://www.vprintinfotech.com Magazine Sat, 22 Mar 2025 14:31:37 +0000 en-US hourly 1 https://wordpress.org/?v=6.7.2 https://www.vprintinfotech.com/wp-content/uploads/2023/08/logo-feb-150x150.jpg #AnimalNutrition – Vprint Infotech https://www.vprintinfotech.com 32 32 Natural Betaine (Anhydrous): The Safer and Superior Alternative to Synthetic Additives Betaine HCl & Choline chloride in Poultry Nutrition https://www.vprintinfotech.com/natural-betaine-anhydrous-the-safer-and-superior-alternative-to-synthetic-additives-betaine-hcl-choline-chloride-in-poultry-nutrition/ https://www.vprintinfotech.com/natural-betaine-anhydrous-the-safer-and-superior-alternative-to-synthetic-additives-betaine-hcl-choline-chloride-in-poultry-nutrition/#respond Sat, 22 Mar 2025 14:31:29 +0000 https://www.vprintinfotech.com/?p=6942 Natural Betaine (Anhydrous): The Safer and Superior Alternative to Synthetic Additives Betaine HCl & Choline chloride in Poultry Nutrition

Dr Bhaskar Choudhary
Animal Nutritionist
Biochem Zusatzstoffe Handels- und Produktionsgesellschaft mbH

 

Abstract:
In the modern poultry industry, ensuring optimal health and productivity in layers, breeders, and broilers under various stress conditions is vital. Feed additives like choline chloride, synthetic betaine (anhydrous and HCl forms), and natural betaine are used to enhance performance. However, synthetic choline chloride and betaine often contain residues of ethylene oxide and trimethylamine (TMA), which pose significant risks to poultry health, including fatty liver syndrome, reproductive challenges, and respiratory hazards. The chemical synthesis of these additives highlights the adverse effects of residue contamination and explains why natural Betaine (anhydrous )(Hepatron/Beta Pro BL) is the superior choice.

 

1. Chemical Synthesis of Choline Chloride, Betaine, and Betaine Hcl
Choline Chloride Synthesis:
Choline chloride is produced by reacting ethylene oxide with trimethylamine, followed by neutralization with hydrochloric acid:
C2H4O + (CH3)3N + HCl —- (CH3)3N+CH2CH2OH.Cl-

Synthetic Betaine Anhydrous Synthesis:
Betaine is synthesized by methylating glycine with trimethylamine:
NH2CH2COOH + 3(CH3)3N—– (CH3)3N+CH2COO-

Betaine Hydrochloride Synthesis:
Betaine HCl is formed by reacting betaine with hydrochloric acid:
(CH3)3N+CH2COO- + HCl —– (CH3)3N+CH2COOH.Cl-

2. Risks Associated with Ethylene Oxide and Trimethylamine Residues
Ethylene Oxide (EO): permissible limit 0.2mg/g
Source: Ethylene oxide is used as a key reactant in choline chloride synthesis.

Risks and Effects:
Fatty Liver: Ethylene oxide residues exacerbate lipid accumulation in the liver, leading to fatty liver syndrome, impairing metabolism and egg production in layers.
Reproductive Challenges: In breeders, EO residues can induce oxidative damage to ovarian tissues, affecting fertility and hatchability.
Respiratory Hazards: Chronic exposure to ethylene oxide fumes or residues increases oxidative stress in respiratory tissues, leading to reduced lung function and increased susceptibility to respiratory infections.

Trimethylamine (TMA): permissible limit 10 mg/kg
Source: TMA is used as a methyl donor in the production of choline chloride and synthetic betaine.

Risks and Effects:
Fatty Liver: Excess TMA disrupts lipid metabolism by impairing the synthesis of very low-density lipoproteins (VLDL), leading to hepatic fat accumulation.
Reproductive Challenges: In breeders, TMA residues interfere with reproductive hormone balance, reducing fertility and chick quality.
Respiratory Hazards: Volatile TMA emissions irritate the respiratory tract, causing chronic respiratory distress in broilers and layers, especially in poorly ventilated environments.

3. Challenges of Synthetic Additives in Poultry Nutrition
Residue Toxicity: Synthetic choline chloride and betaine often leave traces of ethylene oxide and TMA, causing long-term health risks.
Liver Dysfunction: These residues impair liver detoxification and metabolic efficiency, leading to reduced productivity.
Limited Stress Resilience: Synthetic forms lack the bioactive properties of natural betaine, making them less effective in managing stress.

4. Natural Betaine (anhydrous) (Hepatron/Beta Pro BL): A Safer and More Effective Solution
Residue-Free and Safe: Hepatron/Beta Pro BL, derived from natural sources, is free of ethylene oxide and TMA residues, eliminating the associated risks of liver damage, reproductive issues, and respiratory stress.
Superior Liver Support:
– Enhances lipid metabolism, preventing fatty liver syndrome.
– Boosts detoxification pathways to handle feed-related toxins more effectively.
Enhanced Stress Management:
– Natural osmoregulatory properties stabilize cellular hydration under heat and osmotic stress.
– Promotes better feed conversion and growth performance.

5. Correlation Between Natural Betaine and Poultry Health
Fatty Liver Syndrome Prevention: Natural betaine spares choline and methionine in feed, reducing the metabolic burden on the liver and enhancing lipid transport efficiency.
Reproductive Health Support: Hepatron/BetaPro BL optimizes methylation pathways, improving ovarian function, egg production, and hatchability in breeders and layers.
Respiratory Protection: Unlike TMA-containing additives, Hepatron/Beta Pro BL improves cellular hydration and stress tolerance, protecting the respiratory tract from environmental and metabolic stress.

6. Stress in Poultry: A Multi-Faceted Challenge
Types of Stress in Poultry:
1. Environmental Stress: Heat & cold (Environment) stress in broilers & layer
2. Nutritional Stress: Imbalanced diets and mycotoxin contamination.
3. Physiological Stress: Vaccination, debeaking, and transportation.
4. Production Stress: Egg production in layers and rapid growth demands in broilers.

Role of Hepatron/Beta Pro BL in Feed application for Stress Mitigation:
Layers: Reduces egg drop during heat/Cold stress (Environment physiologica stress/ and improves shell quality.
Breeders: Enhances fertility and hatchability under environmental and nutritional stress.
Broilers: Improves growth performance and livability during transportation and heat stress.
Application of Hepatron/BetaPro BL in Drinking water: 6 hours improved water intake during treatment & outbreak condition it is advisable apart from stress mitigation what mentioned in Feed application for quick support as a clinical Nutrition

7. Why Natural Betaine (Hepatron/Beta Pro BL) is Superior

Conclusion
Residues of ethylene oxide and trimethylamine in synthetic choline chloride and betaine pose significant risks to poultry health, including fatty liver, reproductive challenges, and respiratory hazards. Natural (anhydrous )Betaine (Hepatron/Beta Pro BL) offers a safer, residue-free alternative with superior bioavailability and efficacy. By supporting liver function, improving reproductive outcomes, and protecting respiratory health, Hepatron/Beta Pro BL proves indispensable for sustainable and profitable poultry farming.
References are available on request.

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Nuance Biotechechnology: Pioneering Innovations in Feed Additives https://www.vprintinfotech.com/nuance-biotechechnology-pioneering-innovations-in-feed-additives/ https://www.vprintinfotech.com/nuance-biotechechnology-pioneering-innovations-in-feed-additives/#respond Sat, 08 Feb 2025 11:48:33 +0000 https://www.vprintinfotech.com/?p=6914

Nuance Biotechnology, a rapidly emerging player in the feed additives industry, has made significant strides in 2024 by acquiring two prominent French companies—Global Nutrition International and NutriConcept. This strategic move has bolstered their global footprint, expanded R&D capabilities and facilitated their entry into key markets, including India. Poultry Creations, along with other poultry media, had the privilege of speaking with Dr. Nemanja Todorovic, Chief Business Officer and Mr. Joginder Singh Uppal, Business Director, South Asia, during the 35th AGM of the Poultry Federation of India in Gurugram to discuss their vision, innovations and plans for the Indian market

Entering the Indian Market and Expansion Strategies:

When did Nuance Biotech enter the Indian market and what are your strategies for expansion?
Dr. Nemanja Todorovic: India is not just a country; it is a continent in itself with immense potential in biotechnology and livestock. Recognizing this, we have appointed knowledgeable professionals like Mr. Uppal to lead our initiatives. Our key strategies include:
1. Forging strategic partnerships with key industry players.
2. Expanding distribution networks for broader market penetration.
3. Collaborating with research institutions to localize our products.
4. Educating farmers on the benefits of postbiotics and other innovations tailored to Indian conditions.”

Joginder Singh Uppal: “We launched our South Asian operations in June 2024 with a strong focus on poultry and dairy. Our flagship products, Nu.biom Aves for poultry and Nu.biom Bos for dairy, enhance resilience, performance and farm profitability. Our goal is to empower farmers through innovative solutions backed by scientific research and technical expertise.”

Understanding Postbiotics

Question: Can you explain the difference between postbiotics and other types of biotics?
Dr. Nemanja Todorovic: “Biotics are broadly categorized into prebiotics, probiotics, and postbiotics:
1. Prebiotics serve as a nutrient source for beneficial gut bacteria.
2. Probiotics are live microorganisms that improve gut health.
3. Postbiotics are metabolic byproducts of probiotics, offering stable and targeted benefits without the viability concerns of probiotics.

Our postbiotics enhance gut microbiota balance, optimize nutrient utilization and contribute to immune modulation. Imagine prebiotics as soil, probiotics as rice growing in the field and postbiotics as rice noodles ready for consumption.”

Tailoring Solutions for the Indian Market

Question: How does Nuance Biotech cater to the unique needs of the Indian market?
Joginder Singh Uppal: “We offer tailored solutions to address challenges in poultry and dairy farming, such as:
Postbiotics: A novel concept with proven benefits for immunity, egg quality and overall productivity.
Global Biotics: Products like mycotoxin binders (e.g., Global Fix) and acidifiers that address vital industry concerns.

Our goal is to support farmers with innovative products backed by research, while also educating them about sustainable and profitable farming practices.”

Market Strategy and Customer Engagement

Question: Who is your primary target in the market—feed mills, breeders, GP operators, commercial broiler farmers or integrators?
Joginder Singh Uppal: “Our primary focus is on feed mills since our products are predominantly feed additives. About 60-70% of the industry relies on feed, making this our initial target. Our secondary focus is integrators and large-scale farmers, including layer farmers who produce their own feed. Products like NutriGut and Globacid DW are designed for these segments.”

Unique Selling Proposition and Market Entry

Question: With several toxin binders and acidifiers in the market, what makes your products stand out?
Dr. Nemanja Todorovic: “Our precision production technology sets us apart. From raw material selection and fermentation to production and quality control, every step is meticulously executed. Our R&D-driven approach ensures high efficacy. Global Nutrition, part of our portfolio, has been a trusted name since 2002, exporting to over 40 countries. This global presence underscores the reliability and effectiveness of our products.”

Question: Have your products been introduced to the Indian market yet?
Dr. Nemanja Todorovic: “We commenced operations in mid-2024, focusing on key partnerships and collaborations. Our first consignment is scheduled to arrive next month, allowing us to engage with clients and initiate trials. Discussions with several companies are already underway.”

Future Innovations and Long-Term Vision

Question: Can you share upcoming innovations or product launches for the Indian poultry sector?
Joginder Singh Uppal: “Our focus extends beyond product launches—we provide integrated solutions. Enhancing animal resilience is at the core of our philosophy. By leveraging our expertise in microbial metabolites, we develop solutions tailored to specific market needs. While poultry and dairy remain our primary sectors, we are continuously evolving to address industry challenges.”

Question: What are your long-term plans for the Indian market?
Dr. Nemanja Todorovic: “Our strategy is structured around three key phases:
1. Establishing Partnerships – We have made significant progress in forging valuable collaborations.
2. Regional Expansion – In addition to India, we are targeting Pakistan, Bangladesh, Nepal and Sri Lanka.
3. Direct Sales and Marketing – While working with distributors for outreach, we also plan to engage directly with key accounts representing 50-60% of the poultry industry.”

Sustainability and Industry Challenges

 

Question: What steps is Nuance Biotech taking to ensure product sustainability?
Dr. Nemanja Todorovic: “Sustainability is at the core of our innovation strategy. We focus on enhancing nutrient utilization, reducing waste and minimizing environmental impact. For example, our solutions target ammonia control in poultry and aquaculture. Additionally, our postbiotic solutions have shown promise in reducing methane emissions in dairy cattle, and we plan to conduct further trials in India with leading research institutions.”

Question: Unlike poultry, the Indian dairy sector consists largely of unorganized small farmers. How does Nuance Biotechnology plan to support them?
Dr. Nemanja Todorovic: “About 80% of India’s dairy farmers operate at a small scale. We aim to reach them through a three-pronged strategy:
1. Strengthening our distribution network to enhance accessibility.
2. Focusing on large dairy operations that drive significant market influence.
3. Leveraging veterinary shops as a direct channel for small-scale farmers, a model that has succeeded in similar markets.”

In conclusion, Nuance Biotech is positioning itself as a pioneering force in the feed additives sector, committed to innovation, sustainability and farmer education. As they expand their presence in India and beyond, their solutions promise to enhance efficiency, profitability and resilience in the livestock industry.

 

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ZAGRO SINGAPORE Expands Manufacturing with New Facility in India https://www.vprintinfotech.com/zagro-singapore-expands-manufacturing-with-new-facility-in-india/ https://www.vprintinfotech.com/zagro-singapore-expands-manufacturing-with-new-facility-in-india/#respond Thu, 23 Jan 2025 06:59:53 +0000 https://www.vprintinfotech.com/?p=6866

ZAGRO SINGAPORE Expands Manufacturing with New Facility in India

ZAGRO Singapore, along with its subsidiary PL Agro Technologies Ltd is seen to be bringing a revolution in animal nutrition. PL Agro Technologies Ltd. India, located in Chennai was acquired by ZAGRO Singapore in 2023.

ZAGRO Singapore, a renowned leader in animal health and nutrition, is reinforcing its commitment to providing innovative and high-quality solutions across the global animal nutrition market. Through its strategic acquisition of PL Agro Technologies Ltd. in 2023, ZAGRO has solidified its presence in India, where it now operates a state-of-the-art manufacturing facility in Chennai, further enhancing its pan India footprint and product offerings.

The partnership between ZAGRO Singapore and PL Agro Technologies Ltd. marks a pivotal moment in the company’s journey, enabling it to expand its capacity for production while ensuring that the products are locally relevant and cost-effective for the Indian and global markets. At the heart of this expansion is the PL Agro facility, which now serves as the dedicated production hub for a comprehensive range of animal nutrition products designed to support the poultry industry and other animal health sectors.

The facility manufactures a variety of important products, including mineral premixes (both organic and inorganic), mycotoxin binders, Halquinol, oral liquids, Tiamulin 80% and customized products. These offerings are crafted to meet the diverse and evolving needs of the industry, providing solutions that not only enhance animal health but also ensure performance consistency and cost-efficiency.

ZAGRO Singapore’s decision to produce at the PL Agro facility is rooted in its unwavering confidence in the operational excellence of the plant, which boasts cutting-edge manufacturing capabilities and world-class quality control measures. The strategic importance of this facility is amplified by its ability to meet the increasing demand for high-quality animal nutrition solutions, all while maintaining local production standards and ensuring compliance with international regulations.
ZAGRO remains steadfast in its commitment to its core philosophy: “Global Technology, Local production and effective Solutions.” This guiding principle drives the company to deliver high-quality products tailored to local needs while adhering to global standards. Through sustainable practices and innovation, ZAGRO focuses on building long-term, reliable relationships with customers, distributors, and industry stakeholders across the globe.

The establishment of the PL Agro facility as the main production hub underscores ZAGRO’s long-term vision for India as a strategic market and a vital part of its global operations. With this move, Zagro aims to increase its market penetration, reduce product lead times, and enhance its responsiveness to customer needs.

Furthermore, ZAGRO Singapore is keen on engaging more directly with the poultry and animal health industries. The company’s goal for 2025 is to further strengthen its connections with poultry farmers, veterinarians, feed millers, and other industry professionals throughout India. This initiative aims to create stronger bonds, understand customer demands better, and offer even more tailored solutions.
For further inquiries or more detailed information, please contact:

Mr. Manas Mitra
Head of Business Operations, Zagro India
Email: manas.mitra@zagro.com

For Technical Assistance / Product Information
Mr. Raja Vadivel
R&D Project Manager, Zagro Singapore
Email: raja.vadivel@zagro.com

Visit our company websites for more information about us.
www.plagro.in
www.zagro.com

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An Overview of Activated Guanidinoacetic Acid (GAA) in Poultry Nutrition: Optimizing Feed Cost, Performance and Profitability https://www.vprintinfotech.com/an-overview-of-activated-guanidinoacetic-acid-gaa-in-poultry-nutrition-optimizing-feed-cost-performance-and-profitability/ https://www.vprintinfotech.com/an-overview-of-activated-guanidinoacetic-acid-gaa-in-poultry-nutrition-optimizing-feed-cost-performance-and-profitability/#respond Wed, 06 Nov 2024 12:25:29 +0000 https://www.vprintinfotech.com/?p=6701

Poultry production is one of the most advanced agricultural industries, playing a key role in the global food supply. While the poultry industry works to meet the rising demand for high-quality protein, the availability and cost of feed ingredients remain significant challenges for the poultry sector. Poultry feed accounts for more than 70% of total production costs, making it the largest expense in poultry farming. Fluctuations in the prices of key ingredients like corn and soybean meal, driven by global markets and climate conditions, significantly impact feed costs. Moreover, dependency on corn and oil as major energy sources in poultry feed, along with competition for these commodities from biofuel and human food industries, further drives prices up the poultry feed cost.

Ways (Strategies) to Reduce Poultry Feed Cost
1. Feed cost optimization through least cost formulation by use of software and precision nutrition by use of synthetic amino acids i.e. Lysine, Methionine, Threonine, Valine, Tryptophan, Arginine, etc. is a common practice followed by industry since the last three decades.
2. Enhancing dietary energy utilization is important and constantly under investigation. Application of feed additives i.e. exogenous enzymes (Amylase, Xylanases, ß-glucanase, α-Galactosidase, β-Mannanase, Protease, Phytase, etc.), and fat emulsifier to improve digestion and improve the availability of nutrients for absorption from the gut. By using an enzyme in poultry feed, poultry producers can reduce feed costs.
3. Cellular Energy: A key strategy for enhancing cellular metabolic efficiency is the use of Guanidinoacetic acid (GAA). GAA (C3H7N3O2) is an amino acid derivative, formed de-novo from L-arginine and L-glycine. It is the only precursor for creatine which plays a significant role in energy metabolism. GAA plays a crucial role in supporting cellular metabolism by ensuring optimal ATP availability, the primary energy source for cellular functions.
GAA, Adenosine Triphosphate (ATP), and Cellular Energy
After feed digestion, nutrients such as glucose, amino acids, and fatty acids are absorbed into the bloodstream and delivered to cells, where they are used to produce Adenosine Triphosphate (ATP) through various metabolic pathways. ATP serves as the cell’s primary energy source, often referred to as the “energy currency” because its stored energy is readily released when the bond between its second and third phosphate groups is broken, generating about 8 kcal/mole upon conversion to adenosine diphosphate (ADP).

ATP is fundamental for energy-intensive processes like muscle growth, egg production, sperm motility, nutrient absorption, immune response, and heat stress resilience.

Birds need more ATP & ATP deficiency can occur in the body in various conditions 
  • Rapid & fast growth -Where important amounts of ATP are absorbed for protein synthesis
  • Excitement or stress – Not only for escape but also for macrophages to fight pathogens
  • Low oxygen supply – Leading to low ATP production
  • Disturbed energy metabolism -Impaired mitochondrial function (Oxidative stress)
  • Low feed consumption especially in extreme summer
By ensuring a continuous supply of ATP, poultry can achieve better growth rates, improved reproductive performance, enhanced feed conversion efficiency, and overall health.

Guanidinoacetic acid (GAA)
plays a key role in cellular energy metabolism because it is the single immediate precursor of creatine. Creatine converts to creatine phosphate which is a key energy reserve in the body, and it helps to avoid the depletion of cellular ATP through the immediate provision of high-energy phosphates to regenerate the ATP molecule from adenosine diphosphate.

Although birds synthesize GAA and creatine from glycine and arginine amino acids, the endogenous production is insufficient to meet the demands of high performance and growth of modern broilers & breeders. So, GAA supplementation via the diet is beneficial for poultry. GAA requires the body’s nutrients for methylation and transferase enzyme to convert into creatine, which can be compromised under several situations such as climatic and production stress, leading to poor creatine delivery and reduced performance. In contrast, activated GAA (GAA along with methyl donor and transferase enzymes) bypasses these processes (methylation and enzyme synthesis), converting more efficiently into creatine in the body, ensuring high creatine levels, energy-sparing activity, arginine-sparing activity, and performance.

 

(Synthesis and metabolism of Guanidinoacetic acid (Image taken Krueger et al., 2010 & modified)

 

 

(Breakdown of ATP and release Energy)

The formation of GAA from L-Arginine and Glycine is regulated by a negative feedback mechanism involving both serum creatine and ornithine concentrations on L-Arg: Gly amidino transferase enzyme activity. However, dietary GAA supplements would bypass this rate-regulating mechanism. Therefore, increasing the dietary supply of L-arginine and Glycine would not increase creatine synthesis or its concentrations in muscle tissue beyond such regulated levels. De Groote, Braun, and Dilger (2018) reported muscle and serum creatine levels to be higher with supplemental GAA, compared to L-Arginine.
GAA (mg/kg) & Creatine (mg/kg) in different Feed Ingredients
Creatine is available only in animal protein-based feed ingredients. Its availability from external sources is questionable because creatine is heat-labile, and the rendering process temperature affects its levels in feed. A plant-based (vegetable) diet and its ingredients do not contain GAA and creatine.
Table 1. Feed ingredients contain Guanidinoacetic acid (GAA), creatine, and creatinine. (Krueger, Damme, and Lemme 2010).
Creatine requirements of modern broilers (adapted & modified form Khajali, et.al (2020)
A 21-day-old broiler chicken (985 g on average) with an average daily weight gain of 75 g (Aviagen 2019) would require 169 mg creatine.
The calculation is based on the assumption that 50% of weight gain is muscle (Kallweit et al., 1988) and muscle tissue contains 4.5 g/kg creatine (Lemme et al., 2007). For a more exact calculation of the CREA requirement, its turnover needs to be considered, as suggested by Tossenberger et al., (2016). Heat instability is the main issue that limits the use of creatine as a feed supplement for poultry (Vranes et al., 2017) because poultry diets are most often subjected to feed processing (pelleting) which imposes heat exposure of 70°C or higher (Slominski 2011).
Supplementation of GAA in Poultry Feed 
GAA, a direct precursor of CREA, has recently attracted attention as a feed additive for poultry due to its high thermal stability (Vranes et al., 2017), which makes it relatively stable during pelleting or extruding.
  • GAA has been officially registered as an animal feed additive by the EFSA (European Food Safety Authority) (2009; 2022) & the US-FDA (U. S. Food and Drug Administration)
  • GAA supplements account for 40% less cost compared to creatine.
  • GAA exerts many non-creatine roles, including the stimulation of insulin secretion, neuromodulation, and vasodilation.
  • GAA has an arginine-sparing potential of up to 149% in broilers, thus arginine is more readily available for metabolic processes other than GAA production
Effect of GAA on Poultry Performance
– Reduce feed cost & lower production cost
– Improve feed conversion ratio (FCR)
– Increase body weight gain, breast meat yield & dressing percentage
– Reduce muscle degeneration problems
– Improve semen quality & fertility – male breeders
– Improve chick quality – female breeder
– Reduce heat stress mortality & ascites
How GAA Optimizes Poultry Performance: In-Depth Look

1. Reduce feed cost (lower production cost) & Improve feed conversion ratio (FCR)

o Guanidinoacetic acid (GAA) is key in creatine synthesis, enhancing energy storage and transfer within muscle cells. Creatine, stored as phosphocreatine, supports the quick regeneration of ATP, which powers energy-intensive processes like muscle contraction, growth, and protein synthesis. GAA supplementation in poultry diets optimizes energy recycling, resulting in improved energy utilization and performance.

o As GAA enhances the bird’s endogenous creatine production, improving energy efficiency. This cellular energy efficiency allows nutritionists to reduce feed costs by lowering metabolizable energy (ME) by 30-60 kcal/kg at an inclusion rate of GAA @ 600 g/ton without affecting growth performance while reducing energy-rich ingredients like maize & oil.
o Furthermore, GAA is effective in low-protein diets also, enabling reduced crude protein levels without compromising performance. Studies show that supplementing GAA at 600-1200 g/ton in low-CP diets maintains optimal growth and carcass quality while reducing protein-rich ingredients like soybean meal.
o GAA has an arginine-sparing effect that reduces dietary arginine requirements by 10-15%, freeing up arginine for other vital functions and lowering feed costs.
o Lastly, GAA supplementation significantly improves the feed conversion ratio (FCR), reducing feed intake per unit of weight gain. Research indicates that GAA can improve FCR by 4.5 to 8.8 points, leading to more efficient growth and lower overall feed costs.
2. Increase body weight, breast meat yield, and meat quality 
o GAA supplementation increases creatine availability, supporting enhanced muscle energy metabolism. This translates to improved muscle growth in fast-growing broilers. Better energy delivery to muscle cells means more efficient feed utilization, promoting higher meat yield. Research has shown that supplementing broiler diets with GAA @ 600-1200 g/ton feed, leads to noticeable performance improvements, including significant gains in breast muscle mass, a highly valuable part of the poultry carcass. This contributes to both higher carcass quality and profitability.
o Dietary supplementation of GAA @ 1200 g/ton feed contributed to improving meat quality via ameliorating muscle energy expenditure and delaying anaerobic glycolysis of broilers. GAA supplementation in broiler diets may be an effective tool for improving meat quality by reducing myopathy severity including woody breast, white striping, and woody-like tender in heavy broilers.
3. Role of Guanidinoacetic Acid (GAA) in Broiler Breeders
o Guanidinoacetic Acid (GAA) supplementation offers multiple benefits in broiler breeders, enhancing fertility, hatchability, and chick quality. Studies have shown that GAA supplementation improves egg production and consistency. It also increases breeder vitality, enabling efficient mating in males and enhancing reproductive performance in deep litter systems.
o In male breeders, GAA plays a crucial role in improving fertility by enhancing sperm quality and viability. It supports the functioning of Sertoli cells, crucial for spermatogenesis, and increases ATP availability, resulting in higher sperm motility and better penetration capabilities. Improved sperm quality leads to higher fertility rates, and GAA supplementation helps prevent age-related reproductive deficits.
o In female breeders, GAA supplementation boosts creatine content in hatching eggs, supporting embryo development during crucial stages like organogenesis and skeletal formation. This leads to better hatchability, chick vitality, and postnatal growth.
o Supplementation of broiler breeder diets with GAA @ 1000-1200 g/ton feed is a promising strategy for optimizing the productivity, fertility, and hatchability of breeder birds, ultimately contributing to improved chick performance and overall flock efficiency.
4. Effect of GAA on heat stress mitigation
o During acute heat stress, the cellular energy demand increases and during chronic heat stress, mitochondrial adenosine triphosphate (ATP) generation is reduced. In addition, heat stress induces higher utilization of muscle energy reserves in the form of glycogen. On this note, it could be perceived that enhancing the cellular creatine-phosphocreatine energy shuttle system might offer benefits for the broiler subjected to heat stress. Indeed, this system functions as a backup to the adenosine ADP-ATP cycle to store and mobilize energy when required on short notice. GAA feeding improved survival during heat stress, supported by lower panting frequency. Another primary physiological response during HS is the increased blood flow to the body surface or upper respiratory tract to dissipate internal body heat (Yahav et al., 1997). Therefore, the blood flow to some visceral organs is significantly reduced. In this respect, Arginine plays a pivotal role as it is the nitrogenous precursor for the endogenous synthesis of nitric oxide by nitric oxide synthase. Nitric oxide is a potent vasodilator that directly relaxes vascular smooth muscle and modulates or inhibits the production and release of vasoconstrictors such as serotonin. Higher Arginine bioavailability might thus be beneficial for heat-stressed birds, as it has been demonstrated in Pekin ducks (Zhu et al., 2014). Furthermore, conclusively, it was demonstrated that dietary-supplemented GAA is able to spare Arginine in broilers (Dilger et al., 2013; DeGroot et al., 2018). Consequently, more Arginine would be available for its protein and other nonprotein functions, such as a precursor for nitric oxide and polyamines. GAA supplementation improved feed conversion ratio and survival, with the largest benefits in the finisher period when birds were subjected to heat stress.
Conclusion
In conclusion, Guanidinoacetic Acid (GAA) supplementation in poultry diets offers a multiple benefit in poultry. GAA supplementation in poultry diets allow to reduce feed cost, improves feed conversion ratios, increases body weight gain, and boosts breast meat yield. It effectively supports muscle growth, mitigates muscle degeneration issues, and enhances meat quality by reducing the severity of myopathies. In broiler breeders, GAA improves reproductive performance by increasing sperm quality and fertility in males while boosting egg and chick quality in females. Additionally, GAA enhances resilience to heat stress, leading to improved survival rates and economic profitability under challenging conditions. This makes GAA a valuable tool for optimizing poultry productivity, profitability, and overall flock health.
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CINNAMALDEHYDE-Everything the plants have that you want- LEARNING BY DOING SCIENCE… https://www.vprintinfotech.com/cinnamaldehyde-everything-the-plants-have-that-you-want-learning-by-doing-science/ https://www.vprintinfotech.com/cinnamaldehyde-everything-the-plants-have-that-you-want-learning-by-doing-science/#respond Wed, 06 Nov 2024 11:08:51 +0000 https://www.vprintinfotech.com/?p=6687 CINNAMALDEHYDE-Everything the plants have that you want- LEARNING BY DOING SCIENCE…

Deep Chand Vashishtha, – M.Sc, MBA
NSM- Bioncia International Pvt Ltd

Science is a novel practise to allow potential of ingredients or elements. It will be very helpful when it meets your requirements So well said that Learning by Doing Science…Plant bioactive compounds, such as phytochemicals, in poultry diets, are gaining popularity due to their potential antioxidant and anti-microbial activities. Phytogenic feed additives (PFAs) have emerged as natural alternatives to antibiotic growth promotors and have great potential in the poultry industry. In recent years, cinnamon (one of the most widely used spices) has attracted attention from researchers as a natural product with numerous health benefits for poultry. The essential oils in cinnamon, in particular, are of interest because of their antioxidant, anti-microbial, anti-inflammatory, antifungal, and hypocholesterolaemic effects, in addition to their ability to stimulate digestive enzymes in the gut.

Know Values of Poultry Industries
India Poultry Feed Market was valued at USD 3.27 billion in 2024 and is anticipated to project impressive growth in the forecast period with a CAGR of 6.21% through 2030.17 Sept 2024The demand for poultry feed is expected to increase due to the country’s growing poultry production, the expanding retail and food service industry, and advancements in poultry breeding techniques. However, high feed costs may put downward pressure on demand.

CINNAMALDEHYDE
Cinnamon belongs to the genus Cinnamomum (Lauraceae family) which contains more than 250–300 aromatic evergreen shrubs and plant trees However, only a few of these species have significant economic importance worldwide as a common spice including Cinnamomum zeylanicum (C. zeylanicum: True Sri Lankan cinnamon), C. cassia (Chinese cinnamon), C. burmanni (Indonesian cinnamon) and C. loureiori (Vietnamese cinnamon). The annual production of cinnamon is around 0.23 million metric tons, mainly cultivated in Indonesia, Sri Lanka, China, India, Vietnam, and Madagascar.

Phytochemistry Of Cinnamaldehyde
Phytochemicals are plant bioactive non-nutritive compounds that are usually found in small quantities They have different classes according to their structure and include phenolic compounds, phytosterols, phytoestrogens, glucosinolates, saponins, terpenoids, protease inhibitors and organo-sulfur containing compounds. They have significant antioxidant capacity to reduce and protect oxidative stress. Cinnamon consists of various bioactive compounds. Modern analytical techniques have enabled the characterization, identification, purification and quantification of individual compounds and the study of their potent biological activities. Generally, gas chromatography is applied to characterize volatile compounds while liquid chromatography for the identification of phenolic compounds. It is documented that cinnamon consists of natural antioxidant, anti-microbial and anti-inflammatory components such as volatile oils, flavonoids, curcuminoids, coumarins, tannins, alkaloids, xanthones, terpenoids, phenolics and other compounds in significant amounts. The concentration of volatile compounds in cinnamon essential oil (CNO) mainly depends upon the plant parts (leaves, bark, root, stem) from which it is extracted. About forty-one volatile compounds were identified from the bark oil of cinnamon (C. cassia) tree. Cinnamaldehyde (55% to 78%) is the main flavor compound in CNO extracted from bark while eugenol (59–78%) is the main compound in CNO that is extracted from leaves. The volatile oil is approximately 0.6–1% and 1–2% phlobatannins, calcium oxalate, starch, mucilage, and mannitol (sweet) in the bark. Moreover, Kim, et al. further investigated the cinnamon bark oil through GC-MS (gas chromatography– mass spectrometry) and identified seventeen different bioactive compounds. The major bioactive compounds of cinnamon are cinnamaldehyde, cinnamate, cinnamic acid, all of which play vital roles in various biological activities. The different essential oils that have been reported in cinnamon include trans-cinnamaldehyde, eugenol, cinnamyl acetate, L-borneol, L-bornyl acetate, β-caryophyllene, caryophyllene oxide, E-nerolidol, α-thujene, α-cubebene, terpinolene and α-terpine [19]. The LC-MS (liquid chromatography–mass spectrometry) analysis has shown that the concentrations of condensed tannins, proanthocyanidins (PAs) and epicatechin in cinnamon are 26.8%, 23.2% and 3.6%, respectively. Cinnamon has a high polyphenol content and the anthocyanidins (A and B procyanidins) are also present in cinnamon

Poultry Gut Health

Efficient immune system development and proper digestion and absorption of feed, water, and electrolyte balance in the gut leads to the development of strong gut health in poultry. The gut ecosystem plays a vital role in eliminating toxins and infectious agents from the intestinal tract of the poultry. Many factors influence the gut microbial ecosystem, including feed additives (phytobiotics, prebiotics, probiotics, feed enzymes, organic acids etc.), feed composition, genetics, heat stress, feeding practices on the poultry farm, among others. These factors exert a substantial impact on the gut microbiota and poultry health. The association between gut health and poultry performance is widely accepted with optimal health including proper physiological functions of the intestinal tract, morphological integrity, efficient immune response, developed barrier functions, energy balance, tissue metabolism, sustained inflammatory balance and sufficient microbiota to perform desired functions in the gut. The health of poultry is influenced by the structure and functionality of gut microbiota. The progression of acquisition and maturation of the intestinal microbiota throughout the growth period of the poultry has a marked impact on the modulation of physiological functions (nutrient digestion, immunity, intestinal barrier integrity etc.) to maintain gut homeostasis and development of the intestinal epithelium. These functions are essential to optimize energy use and efficiency of extraction by the poultry birds.

Impact of Cinnamon on the Digestibility of Nutrients
Improved utilization of feed improves the feed conversion ratio (FCR), body weight gain (BWG) and overall health performance of broiler chicken. The stabilization of the gut microbiota ecosystem and the stimulation of digestive enzymes secretion are the two well-accepted mechanisms that play a leading role in improving feed utilization and inhibiting the growth-depressing ailments related to metabolism and digestion. The potential impacts of CNO on the secretion of digestive enzymes from the intestinal mucosa and pancreas have been described in many poultry studies. These positive impacts had been confirmed to improve the digestibility of nutrients. Additionally, the bioactive compounds of cinnamon affect lipid metabolism by transporting the fatty acids in the digestive tract of broilers. The CNO has positive effects on the secretion of digestive enzymes and improves the digestibility of nutrients in the gut.

Supplementation of CNO in broilers diet increased the villus height (VH) in the duodenum and jejunum with associated increased villus surface area and the efficiency of absorption and digestion of nutrients. In addition, a greater VH means greater mucosal digestive enzyme activity, which ultimately improves the digestibility of nutrients.
To sum up, the use of cinnamon and its bioactive compounds as feed additives in poultry diets have potent effects on antioxidant status, immunity, nutrients availability and digestibility, enzymes secretion, mucus production, gut microbiota and overall poultry health, growth performance and productivity

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NUQO expands team in South Asia by Welcoming Reena Rani as Head of Marketing, South Asia https://www.vprintinfotech.com/nuqo-expands-team-in-south-asia-by-welcoming-reena-rani-as-head-of-marketing-south-asia/ https://www.vprintinfotech.com/nuqo-expands-team-in-south-asia-by-welcoming-reena-rani-as-head-of-marketing-south-asia/#respond Fri, 18 Oct 2024 11:08:37 +0000 https://www.vprintinfotech.com/?p=6659
Bengaluru, 18th Oct 2024 – NUQO Animal Nutrition India Pvt. Ltd., a leader in innovative animal nutrition solutions, is excited to announce the appointment of Reena Rani as Head of Marketing, South Asia. In this role, Reena will oversee all marketing functions and will lead strategies & key initiatives of NUQO in the South Asia region and will be driving growth and engagement across key markets.

Reena brings over 12 years of extensive experience in marketing. Campaigns, pricing strategy, digital marketing, content creation, social media strategy, branding, marketing communication, and business analytics are her core strengths. Her deep expertise spans across top industry players such as Cargill and Novus, where she developed and implemented marketing programs that delivered measurable success.

With a strong academic background, Reena holds a master’s degree in industrial chemistry and an advanced Diploma in Digital Marketing and Analytics from the prestigious Indian Institute of Management, Kozhikode (IIMK). Her blend of technical knowledge and strategic marketing insights makes her a valuable addition to NUQO India’s leadership team.


Ewenn Helary, CEO
NUQO Feed Additives

“We are thrilled to have Reena join us at NUQO. Her proven ability to lead and execute innovative marketing strategies will be instrumental in expanding our presence in South Asia,” said Ewenn Helary, CEO at NUQO Feed Additives. “We are confident that Reena’s leadership will bring fresh perspectives and help elevate our brand in the region.”


Neeraj Kumar Srivastava
Managing Director, South Asia
NUQO Feed Additives

“We are delighted to welcome Reena to the NUQO team. Her deep understanding of the South Asia market and her exceptional track record in marketing make her the perfect fit to lead our efforts in this important region. Reena’s leadership will help us strengthen our marketing capabilities and further solidify NUQO’s position as a leader in animal nutrition solutions. We look forward to the innovative strategies she will bring to the table,” said Neeraj Kumar Srivastava – Managing Director, South Asia.


Stephanie Ladirat, Technology Director
NUQO Feed Additives

“We are thrilled to welcome Reena to the NUQO team. She brings a unique blend of technical expertise and sharp strategic marketing insight,” said Stephanie Ladirat, Technology Director at NUQO Feed Additives. “Her skills and vision will be key assets as we drive growth and innovation in South Asia market. We are looking forward to collaborating with her and see her talents and ideas flourish”

Reena’s appointment comes at a pivotal time for NUQO as the company continues to expand its footprint in the global animal nutrition market. Her role will be crucial in driving customer engagement and market penetration, further positioning NUQO as a trusted provider of natural, sustainable animal nutrition solutions.

About NUQO Feed Additives
NUQO© is a pioneer in combining phytogenics & phycogenics with a unique and cutting-edge micro- encapsulation technology that preserves efficacy and ensures optimal release of active ingredients.

Based on this expertise, NUQO© promotes various solutions that help professionals to better address challenges related to performance, health or welfare of animals.

For more information, please contact: info@nuqo.eu

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